iPTMnet Report for P61201 (COPS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P61201 / CSN2_HUMAN
Protein Name COP9 signalosome complex subunit 2
Gene Name Name: COPS2
Synonyms:CSN2,TRIP15;
Organism Homo sapiens (Human)

PRO ID PR:P61201
DAG View
PRO Name COP9 signalosome complex subunit 2 (human)
Definition A COP9 signalosome complex subunit 2 that is encoded in the genome of human.
Short Label hCOPS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61201 (COPS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K48 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
Y118 Phosphorylation PhosphoSitePlus
T121 Phosphorylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
Y159 Phosphorylation PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
S221 O-Glycosylation GlyGen 23301498, 35138101, 35254053, ...34019948, 36580660, 28510447
K225 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
Y279 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
N333 N-Glycosylation GlyGen 29671580
R352 Methylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K426 Acetylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y279 Phosphorylation HPRD 20068231
N333 N-Glycosylation PRO 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K56 R56 Biomuta DOID:1324 / lung cancer [ cosmic ]
K64 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S111 F111 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y159 C159 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
Y159 N159 Biomuta DOID:4159 / skin cancer [ cosmic ]
S221 T221 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]