iPTMnet Report for P61160 (ACTR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P61160 / ARP2_HUMAN
Protein Name Actin-related protein 2
Gene Name Name: ACTR2
Synonyms:ARP2;
Organism Homo sapiens (Human)

PRO ID PR:P61160
DAG View
PRO Name actin-related protein 2 (human)
Definition An actin-related protein 2 that is encoded in the genome of human.
Short Label hACTR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61160 (ACTR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 25944712
S3 Phosphorylation PhosphoSitePlus
K7 Ubiquitination PhosphoSitePlus
C11 Methylation IEDB 31844290
K19 Methylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
Y22 Phosphorylation PhosphoSitePlus
T45 Phosphorylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
S62 O-Glycosylation GlyGen 30379171, 34019948, 34725712, ...35138101, 36240223
S62 Phosphorylation PhosphoSitePlus
S66 O-Glycosylation GlyGen 30379171, 34019948, 34725712, ...35138101, 36240223
Y72 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
Y91 Phosphorylation PhosphoSitePlus
T92 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
T117 Phosphorylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
C167 Methylation IEDB 31844290
K195 Ubiquitination PhosphoSitePlus
Y202 Phosphorylation Q99558 (MAP3K14) PhosphoSitePlus   RLIMS-P 18725535, 22125478, 25601402
S207 Phosphorylation PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
C221 Methylation IEDB 31844290
T237 Phosphorylation Q99558 (MAP3K14) PhosphoSitePlus   RLIMS-P 27872092, 18725535, 22125478, ...25601402
T238 Phosphorylation Q99558 (MAP3K14) PhosphoSitePlus   RLIMS-P 27872092, 18725535, 22125478, ...25601402
K253 Ubiquitination PhosphoSitePlus
K299 Acetylation PhosphoSitePlus   UniProt 19608861
K299 Ubiquitination PhosphoSitePlus
S315 O-Glycosylation GlyGen 30379171, 34019948, 34725712, ...35138101, 36240223
K322 Acetylation PhosphoSitePlus   UniProt 19608861
K322 Ubiquitination PhosphoSitePlus
K331 Sumoylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
T374 Phosphorylation PhosphoSitePlus
Y378 Phosphorylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K388 Sumoylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T117 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S67 Phosphorylation HPRD   PhosphoSitePlus 19651622
T122 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O00401 (WASL) Y256 P61160 (ACTR2) unknown eFIP 23212915


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C11 Y11 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K106 N106 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K195 E195 Biomuta DOID:3571 / liver cancer [ cosmic ]
S207 A207 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K253 T253 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T374 S374 Biomuta DOID:2531 / hematologic cancer [ cosmic ]