Protein Information

Cytoscape View

UniProt AC / UniProt ID P61026 / RAB10_HUMAN
Protein Name Ras-related protein Rab-10
Gene Name Name: RAB10
Organism Homo sapiens (Human)

PRO ID PR:P61026
DAG View
PRO Name Ras-related protein Rab-10 (human)
Definition A Ras-related protein Rab-10 that is encoded in the genome of human.
Short Label hRAB10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P61026 (RAB10) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation PhosphoSitePlus
Y6 Phosphorylation HPRD   PhosphoSitePlus 18578522
S18 Phosphorylation PhosphoSitePlus
T23 Phosphorylation RLIMS-P 31624137
T41 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
T50 Phosphorylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
T65 Phosphorylation PhosphoSitePlus
T73 Phosphorylation Q5S007 (LRRK2) IntAct   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29212815, 29562525, 33177079, ...30635421, 29125462, 28860483, 30945962, 30209220, 31527116, 30398148, 31663853, 32601174, 33451735, 26824392, 29305429, 30597610, 29127255
T76 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
K102 Acetylation PhosphoSitePlus   UniProt 19608861
K102 Ubiquitination PhosphoSitePlus   UniProt 31540829
K123 Ubiquitination PhosphoSitePlus
K129 Acetylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus   UniProt 31540829
R147 Methylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus   UniProt 31540829
T165 Phosphorylation PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P61026 (RAB10) T73 unknown eFIP 31663853
Phosphorylation P61026 (RAB10) T73 Q96CV9 (OPTN) increased_association eFIP 30945962
Phosphorylation P61026 (RAB10) T73 Q9ULR3 (PPM1H) unknown eFIP 31663853

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y6 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K49 T49 Biomuta DOID:1115 / sarcoma [ icgc ]
T73 S73 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S77 T77 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S181 I181 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S187 I187 Biomuta DOID:3571 / liver cancer [ icgc ]