iPTMnet Report for P61009 (SPCS3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P61009 / SPCS3_HUMAN
Protein Name Signal peptidase complex subunit 3
Gene Name Name: SPCS3
Synonyms:SPC22;ORFNames:UNQ1841/PRO3567;
Organism Homo sapiens (Human)

PRO ID PR:P61009
DAG View
PRO Name signal peptidase complex subunit 3 (human)
Definition A signal peptidase complex subunit 3 that is encoded in the genome of human.
Short Label hSPCS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61009 (SPCS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
N141 N-Glycosylation GlyGen   UniProt 34388369, 19159218


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K49 T49 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
K108 N108 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K137 T137 Biomuta DOID:10283 / prostate cancer [ icgc ]