iPTMnet Report for P61006 (RAB8A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P61006 / RAB8A_HUMAN
Protein Name Ras-related protein Rab-8A precursor
Gene Name Name: RAB8A
Synonyms:MEL,RAB8;
Organism Homo sapiens (Human)

PRO ID PR:P61006
DAG View
PRO Name Ras-related protein Rab-8A (human)
Definition A Ras-related protein Rab-8A that is encoded in the genome of human.
Short Label hRAB8A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61006 (RAB8A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Acetylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
T4 Phosphorylation PhosphoSitePlus
Y5 Phosphorylation PhosphoSitePlus
Y7 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
T64 Phosphorylation PhosphoSitePlus
T72 Phosphorylation IntAct   PhosphoSitePlus   RLIMS-P   UniProt 32227113, 29125462, 26471730, ...30709905, 30398148, 31663853, 29357897, 26824392, 29482628
T74 Phosphorylation RLIMS-P 26471730
Y77 Phosphorylation PhosphoSitePlus
Y78 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus   RLIMS-P 26471730, 32227113, 31663853, ...31361120
K116 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
S181 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18088087, 17081983, ...20068231
S185 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 18088087, 20068231
K190 Ubiquitination PhosphoSitePlus
T192 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K197 Ubiquitination PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S181 Phosphorylation HPRD 19413330, 18691976, 18088087, ...17081983, 19651622, 18669648, 20068231
S185 Phosphorylation HPRD 19413330, 18691976, 18088087, ...17081983, 19651622, 18669648, 20068231
T192 Phosphorylation HPRD 18669648, 19664995, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P61006 (RAB8A) S111 Q96QF0 (RAB3IP) unknown eFIP 26471730


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K3 N3 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
T49 I49 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T49 A49 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K116 R116 Biomuta DOID:4159 / skin cancer [ cosmic ]
S181 N181 Biomuta DOID:363 / uterine cancer [ icgc ]