iPTMnet Report for P60981 (DSTN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P60981 / DEST_HUMAN
Protein Name Destrin
Gene Name Name: DSTN
Synonyms:ACTDP,DSN;
Organism Homo sapiens (Human)

PRO ID PR:P60981
DAG View
PRO Name destrin (human)
Definition A destrin that is encoded in the genome of human.
Short Label hDSTN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P60981 (DSTN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 19369195, 21406692, ...12665801, 22223895, 20068231, 22814378, 25944712
S3 Phosphorylation P53667 (LIMK1) , Q96S53 (TESK2) , P53671 (LIMK2) PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 21406692, 23186163, ...17081983, 23153585, 15300782, 15660133, 7615564, 11171090, 11418599, 20068231
C12 Methylation IEDB 31844290
Y16 Phosphorylation PhosphoSitePlus
K19 Acetylation PhosphoSitePlus   UniProt 19608861
K19 Ubiquitination PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
K44 Acetylation PhosphoSitePlus
K45 Acetylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
Y85 Phosphorylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
K112 Sumoylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K114 Acetylation PhosphoSitePlus
K114 Sumoylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
Y117 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
K121 Acetylation PhosphoSitePlus
K121 Sumoylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K125 Acetylation PhosphoSitePlus
K127 Acetylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K132 Acetylation PhosphoSitePlus
K132 Sumoylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
C135 S-Nitrosylation dbSNO 2212679, 22126794
C147 S-Nitrosylation dbSNO 19483679
S155 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation Q96S53 (TESK2) HPRD 19413330, 19651622, 11418599, ...20068231
S24 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K44 E44 Biomuta DOID:1324 / lung cancer [ cosmic ]
K69 M69 Biomuta DOID:1324 / lung cancer [ cosmic ]
S88 R88 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
Y117 H117 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K127 Q127 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C135 F135 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]