Protein Information

Cytoscape View


UniProt AC / UniProt ID P60891 / PRPS1_HUMAN
Protein Name Ribose-phosphate pyrophosphokinase 1
Gene Name Name: PRPS1
Organism Homo sapiens (Human)

PRO ID PR:P60891
DAG View
PRO Name ribose-phosphate pyrophosphokinase 1 (human)
Definition A ribose-phosphate pyrophosphokinase 1 that is encoded in the genome of human.
Short Label hPRPS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P60891 (PRPS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
R22 Methylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus   RLIMS-P 31253668
Y146 Phosphorylation PhosphoSitePlus
R156 Methylation PhosphoSitePlus
K176 Acetylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
S180 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   Signor 29074724
R184 Methylation PhosphoSitePlus
K194 Acetylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
R204 Methylation PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
T225 Phosphorylation PhosphoSitePlus   RLIMS-P 27088854
T228 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
Y245 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
Y311 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T40 Phosphorylation HPRD 20068231
S47 Phosphorylation HPRD 20068231
S180 Phosphorylation HPRD 20068231
T303 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R22 L22 Biomuta DOID:3571 / liver cancer [ icgc ]
R22 H22 Biomuta DOID:363 / uterine cancer [ tcga ]
S103 N103 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S103 R103 Biomuta DOID:1324 / lung cancer [ tcga ]
S180 P180 Biomuta DOID:8618 / oral cavity cancer [ icgc ] DOID:2531 / hematologic cancer [ tcga ]
S180 Y180 Biomuta DOID:363 / uterine cancer [ tcga ]
R204 C204 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T242 I242 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K280 R280 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]