Protein Information

Cytoscape View


UniProt AC / UniProt ID P60842 / IF4A1_HUMAN
Protein Name Eukaryotic initiation factor 4A-I
Gene Name Name: EIF4A1
Synonyms:DDX2A,EIF4A;
Organism Homo sapiens (Human)

PRO ID PR:P60842
DAG View
PRO Name eukaryotic initiation factor 4A-I (human)
Definition A eukaryotic initiation factor 4A-I that is encoded in the genome of human.
Short Label hEIF4A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P60842 (EIF4A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 21406692
S4 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y48 Phosphorylation PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
K54 Acetylation PhosphoSitePlus
K54 Methylation PhosphoSitePlus
K54 Sumoylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
C66 S-Nitrosylation dbSNO 19483679
K68 Sumoylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
Y70 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K99 Sumoylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus   UniProt 19608861
K118 Ubiquitination PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
K146 Acetylation PhosphoSitePlus
K146 Sumoylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
T158 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
R168 Methylation PhosphoSitePlus
K174 Acetylation PhosphoSitePlus   UniProt 19608861
K174 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
K193 Methylation PhosphoSitePlus
K193 Sumoylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
K202 Sumoylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
K225 Sumoylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K226 Acetylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K238 Acetylation PhosphoSitePlus
K238 Sumoylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
Y250 Phosphorylation PhosphoSitePlus
R255 Methylation PhosphoSitePlus
K284 Acetylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K291 Acetylation PhosphoSitePlus
K291 Sumoylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K309 Acetylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
R316 Methylation PhosphoSitePlus
S322 O-Glycosylation GlyGen 23301498, 16408927, 28411811, ...30397120, 26374642, 22967762, 30940748, 32119511, 28510447
S323 O-Glycosylation GlyGen 23301498, 16408927, 28411811, ...30397120, 26374642, 22967762, 30940748, 32119511, 28510447
R353 Methylation PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
T377 Phosphorylation PhosphoSitePlus
K381 Acetylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation HPRD 18452278
S42 Phosphorylation HPRD 18452278
T158 Phosphorylation HPRD 18669648
T224 Phosphorylation HPRD 20068231
T393 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 Y2 Biomuta DOID:1909 / melanoma [ cosmic ]
S4 C4 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S78 Y78 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S78 C78 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R168 W168 Biomuta DOID:363 / uterine cancer [ tcga ]
K177 T177 Biomuta DOID:363 / uterine cancer [ tcga ]
S213 L213 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
R255 L255 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R255 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ] DOID:3070 / malignant glioma [ tcga ]
K284 N284 Biomuta DOID:363 / uterine cancer [ tcga ]
K291 N291 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R316 M316 Biomuta DOID:3571 / liver cancer [ icgc ]
S323 R323 Biomuta DOID:1790 / malignant mesothelioma [ tcga ]
T393 N393 Biomuta DOID:3571 / liver cancer [ icgc ]