Protein Information

Cytoscape View


UniProt AC / UniProt ID P60709 / ACTB_HUMAN
Protein Name Actin, cytoplasmic 1
Gene Name Name: ACTB
Organism Homo sapiens (Human)

PRO ID PR:P60709
DAG View
PRO Name actin, cytoplasmic 1 (human)
Definition An actin, cytoplasmic 1 that is encoded in the genome of human.
Short Label hACTB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P60709 (ACTB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO   UniProt 22814378
D2 Acetylation UniProt 19413330, 22223895, 29581253, ...22814378, 30028079, 25944712
S14 Phosphorylation HPRD   PhosphoSitePlus 20058876
C17 S-Nitrosylation dbSNO 26338901
K18 Methylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
R28 Methylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus
K50 Methylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S60 Phosphorylation PhosphoSitePlus
K61 Acetylation PhosphoSitePlus
K61 Sumoylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Methylation PhosphoSitePlus
K68 Sumoylation PhosphoSitePlus
Y69 Phosphorylation PhosphoSitePlus
H73 Methylation PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus
K84 Methylation PhosphoSitePlus   UniProt 23673617
K84 Sumoylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
Y91 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 18083107
T106 Phosphorylation PhosphoSitePlus
K113 Acetylation PhosphoSitePlus
K113 Sumoylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
T162 Phosphorylation PhosphoSitePlus
Y166 Phosphorylation PhosphoSitePlus
Y169 Phosphorylation PhosphoSitePlus
T186 Phosphorylation PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
K191 Acetylation PhosphoSitePlus
K191 Methylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
Y198 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 18083107
S199 Phosphorylation PhosphoSitePlus
T201 Phosphorylation HPRD   PhosphoSitePlus 19664995
T202 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
C217 S-Nitrosylation dbSNO 25040305, 21278135
Y218 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus 15592455
T229 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
Y240 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
C257 S-Nitrosylation dbSNO 26338901
S265 Phosphorylation PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
C272 S-Nitrosylation dbSNO 25040305, 26338901
K284 Sumoylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
C285 S-Nitrosylation dbSNO 19483679, 21278135
K291 Sumoylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
Y294 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455, 18083107, 16497976
T297 Phosphorylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation HPRD   PhosphoSitePlus 16497976
K315 Acetylation PhosphoSitePlus
K315 Sumoylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
T318 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18088087
S323 Phosphorylation PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
K326 Acetylation PhosphoSitePlus
K326 Methylation PhosphoSitePlus
K326 Sumoylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K328 Acetylation PhosphoSitePlus
K328 Sumoylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K336 Sumoylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
C374 S-Nitrosylation dbSNO 26338901


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036179 (hACTB/Ac:1) acM1 PRO
PR:000036900 (hACTB/Phos:1) pY91,pY198,pY218 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 I1 Biomuta DOID:1324 / lung cancer [ tcga ] DOID:2531 / hematologic cancer [ icgc ]
D2 A2 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
D2 N2 Biomuta DOID:4362 / cervical cancer [ tcga ]
R28 Q28 Biomuta DOID:363 / uterine cancer [ tcga ]
R28 W28 Biomuta DOID:1324 / lung cancer [ tcga ]
S33 C33 Biomuta DOID:1324 / lung cancer [ cosmic ]
K50 R50 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S60 T60 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S60 R60 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S60 G60 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T66 I66 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y69 C69 Biomuta DOID:1324 / lung cancer [ tcga ]
H73 D73 Biomuta DOID:3070 / malignant glioma [ cosmic ]
H73 Y73 Biomuta DOID:2531 / hematologic cancer [ icgc ]
T77 S77 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
T89 A89 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y91 C91 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ] DOID:2531 / hematologic cancer [ icgc ]
T120 A120 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y143 N143 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S155 F155 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T160 A160 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T162 A162 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y166 H166 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
Y188 N188 Biomuta DOID:1324 / lung cancer [ cosmic ]
K213 Q213 Biomuta DOID:2531 / hematologic cancer [ icgc ]
C217 F217 Biomuta DOID:0070003 / blastoma [ cosmic ]
C217 Y217 Biomuta DOID:2531 / hematologic cancer [ tcga ]
K238 N238 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S239 N239 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y240 C240 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S265 C265 Biomuta DOID:1909 / melanoma [ tcga ]
S265 A265 Biomuta DOID:4362 / cervical cancer [ tcga ]
K291 T291 Biomuta DOID:0070003 / blastoma [ cosmic ]
Y294 C294 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K326 N326 Biomuta DOID:363 / uterine cancer [ tcga ]
K336 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K336 R336 Biomuta DOID:363 / uterine cancer [ tcga ]
S348 P348 Biomuta DOID:263 / kidney cancer [ icgc, tcga ]
S348 W348 Biomuta DOID:4362 / cervical cancer [ cosmic, tcga ] DOID:11934 / head and neck cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S348 L348 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S368 A368 Biomuta DOID:1324 / lung cancer [ tcga ]
S368 F368 Biomuta DOID:363 / uterine cancer [ tcga ]