Protein Information

Cytoscape View


UniProt AC / UniProt ID P60228 / EIF3E_HUMAN
Protein Name Eukaryotic translation initiation factor 3 subunit E
Gene Name Name: EIF3E
Synonyms:EIF3S6;
Organism Homo sapiens (Human)

PRO ID PR:P60228
DAG View
PRO Name eukaryotic translation initiation factor 3 subunit E (human)
Definition A eukaryotic translation initiation factor 3 subunit E that is encoded in the genome of human.
Short Label hEIF3E
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P60228 (EIF3E) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895, ...17322308
K29 Ubiquitination PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
Y62 Phosphorylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
T161 Phosphorylation HPRD   PhosphoSitePlus 20068231
R163 Methylation PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K275 Acetylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
Y286 Phosphorylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
S399 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19651622, ...18669648, 20068231
Y401 Phosphorylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K409 Sumoylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K425 Acetylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
T439 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y445 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:363 / uterine cancer [ tcga ]
A2 V2 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K41 T41 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K59 N59 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y116 C116 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T161 A161 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K383 E383 Biomuta DOID:2394 / ovarian cancer [ tcga ]
S399 L399 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K407 T407 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K407 N407 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S410 G410 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S410 N410 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S412 F412 Biomuta DOID:1909 / melanoma [ tcga ] DOID:2596 / larynx cancer [ cosmic ]