iPTMnet Report for P60174 (TPI1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P60174 / TPIS_HUMAN
Protein Name Triosephosphate isomerase
Gene Name Name: TPI1
Synonyms:TPI;
Organism Homo sapiens (Human)

PRO ID PR:P60174
DAG View
PRO Name triosephosphate isomerase (human)
Definition A triosephosphate isomerase that is encoded in the genome of human.
Short Label hTPI1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P60174 (TPI1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Acetylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
K14 Acetylation PhosphoSitePlus   UniProt 19608861
K14 Methylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
S21 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...16807684, 19367720, 18669648, 24275569, 17693683, 19690332, 20068231, 17924679
T28 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
K55 Acetylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
C67 Methylation IEDB 31844290
Y68 Phosphorylation PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K69 Methylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
K85 Ubiquitination PhosphoSitePlus
T90 Phosphorylation PhosphoSitePlus
R100 Methylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
K131 Acetylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
R135 Methylation PhosphoSitePlus
T140 Phosphorylation PhosphoSitePlus
K142 Acetylation PhosphoSitePlus
K142 Sumoylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K149 Acetylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K156 Acetylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
T173 Phosphorylation PhosphoSitePlus
K175 Acetylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
T178 Phosphorylation PhosphoSitePlus
K188 Acetylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K194 Acetylation PhosphoSitePlus   UniProt 19608861
K194 Methylation PhosphoSitePlus   UniProt 24129315
K194 Ubiquitination PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
N196 N-Glycosylation GlyGen 24190977
S198 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
Y209 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T214 Phosphorylation PhosphoSitePlus   UniProt 24275569
T217 Phosphorylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus   UniProt 24275569
K238 Acetylation PhosphoSitePlus   UniProt 19608861
K238 Ubiquitination PhosphoSitePlus
K248 Acetylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD 19413330, 17322306, 18767875, ...20058876, 19664995, 18452278, 19651622, 18669648, 18510355, 20068231, 17924679
T28 Phosphorylation HPRD 20068231
T71 Phosphorylation HPRD 20068231
S80 Phosphorylation HPRD 17322306, 19413330
S195 Phosphorylation HPRD 20068231
S198 Phosphorylation HPRD 20068231
S204 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y16 Phosphorylation PhosphoSitePlus
T28 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T28 I28 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
R100 G100 Biomuta DOID:4159 / skin cancer [ cosmic ]
T140 S140 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K160 T160 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T173 A173 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
Y209 H209 Biomuta DOID:4159 / skin cancer [ cosmic ]
S212 F212 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K219 N219 Biomuta DOID:363 / uterine cancer [ icgc ]
K238 E238 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]