Protein Information

Cytoscape View


UniProt AC / UniProt ID P58876 / H2B1D_HUMAN
Protein Name Histone H2B type 1-D
Gene Name Name: H2BC5
Synonyms:H2BFB,HIRIP2,HIST1H2BD;
Organism Homo sapiens (Human)

PRO ID PR:P58876
DAG View
PRO Name histone H2B type 1-D (human)
Definition A histone H2B type 1-D that is encoded in the genome of human.
Short Label hH2BC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P58876 (H2BC5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
M1 Acetylation PRO
T5 Phosphorylation PhosphoSitePlus
K6 Acetylation PRO   PhosphoSitePlus   UniProt 18552846, 19608861, 16283522, ...16627869
K6 Sumoylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
K12 Acetylation PhosphoSitePlus   UniProt 16627869
K13 Acetylation PRO   PhosphoSitePlus   UniProt 18552846, 16283522, 20693536, ...16627869
S15 Phosphorylation PRO   UniProt 12757711
K16 Acetylation PRO   PhosphoSitePlus   UniProt 16283522, 19883641, 16627869
K17 Acetylation PRO   PhosphoSitePlus   UniProt 20693536, 16627869
K21 Acetylation PRO   PhosphoSitePlus   UniProt 18552846, 16283522, 16627869
K21 Methylation PhosphoSitePlus
K21 Sumoylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K24 Acetylation PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus   UniProt 21726816
S37 Phosphorylation PhosphoSitePlus
Y38 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
Y41 Phosphorylation PhosphoSitePlus
Y43 Phosphorylation PhosphoSitePlus
K44 Acetylation PhosphoSitePlus
K44 Methylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K47 Acetylation PRO   PhosphoSitePlus 20693536
K47 Methylation UniProt 16627869
K47 Sumoylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
T53 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
K58 Acetylation PhosphoSitePlus
K58 Methylation UniProt 16627869
K58 Ubiquitination PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
R73 Methylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
R80 Methylation PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
R87 Methylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
R93 Methylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
R100 Methylation PhosphoSitePlus
K109 Acetylation PhosphoSitePlus
K109 Methylation UniProt 16627869
K109 Sumoylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus
K117 Acetylation PhosphoSitePlus
K117 Sumoylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
K121 Acetylation PRO   PhosphoSitePlus 18552846
K121 Sumoylation PhosphoSitePlus
K121 Ubiquitination PRO   PhosphoSitePlus   UniProt 18400894, 16307923, 16627869, ...19575011, 16713563, 18923072, 18832071
Y122 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036258 (hHIST1H2BD/Ac:1) acM1 PRO
PR:000045046 (hHIST1H2BD/InitMet-/Ac:1) acK13 PRO 16283522, 18552846, 20693536
PR:000045047 (hHIST1H2BD/InitMet-/Phos:1) pS15 PRO 12757711
PR:000045048 (hHIST1H2BD/InitMet-/Ac:2) acK21 PRO 16283522, 18552846
PR:000045050 (hHIST1H2BD/InitMet-/Ubiq:1) ubK121 PRO 16307923, 16713563, 18400894, ...18832071, 18923072, 19575011
PR:000045051 (hHIST1H2BD/InitMet-/Ac:3) acK17 PRO 20693536
PR:000045052 (hHIST1H2BD/InitMet-/Ac:4) acK6 PRO 18552846
PR:000045054 (hHIST1H2BD/InitMet-/Ac:5) acK47 PRO 20693536
PR:000045055 (hHIST1H2BD/InitMet-/Ac:6) acK121 PRO 18552846
PR:000045056 (hHIST1H2BD/InitMet-/Ac:7) acK16 PRO 19883641
PR:000047773 (hHIST1H2BD/InitMet-/N6AcLys+) ac PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T5 A5 Biomuta DOID:3571 / liver cancer [ icgc ]
K6 N6 Biomuta DOID:3571 / liver cancer [ icgc ]
K12 Q12 Biomuta DOID:363 / uterine cancer [ tcga ]
K13 N13 Biomuta DOID:1324 / lung cancer [ cosmic ]
K35 R35 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S37 I37 Biomuta DOID:1115 / sarcoma [ tcga ]
S37 C37 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S37 R37 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S37 N37 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S39 * Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:3070 / malignant glioma [ tcga ]
S39 L39 Biomuta DOID:0070003 / blastoma [ cosmic ]
Y41 C41 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
Y43 * Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
K44 N44 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S56 Y56 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S56 C56 Biomuta DOID:169 / neuroendocrine tumor [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S79 F79 Biomuta DOID:2394 / ovarian cancer [ tcga ]
R80 C80 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R87 H87 Biomuta DOID:2531 / hematologic cancer [ icgc ]
R87 G87 Biomuta DOID:1324 / lung cancer [ cosmic ]
S88 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S88 W88 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T89 A89 Biomuta DOID:1612 / breast cancer [ cosmic ]
S92 P92 Biomuta DOID:3963 / thyroid carcinoma [ icgc, tcga ]
R100 H100 Biomuta DOID:1324 / lung cancer [ tcga ]
K109 Q109 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T116 S116 Biomuta DOID:11054 / urinary bladder cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
Y122 C122 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y122 H122 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
T123 A123 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
S124 N124 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ icgc ]
S124 T124 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K126 N126 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]