Protein Information

Cytoscape View


UniProt AC / UniProt ID P58397 / ATS12_HUMAN
Protein Name A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor
Gene Name Name: ADAMTS12
ORFNames:UNQ1918/PRO4389;
Organism Homo sapiens (Human)

PRO ID PR:P58397
DAG View
PRO Name a disintegrin and metalloproteinase with thrombospondin motifs 12 (human)
Definition An a disintegrin and metalloproteinase with thrombospondin motifs 12 that is encoded in the genome of human.
Short Label hADAMTS12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P58397 (ADAMTS12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y52 Phosphorylation PhosphoSitePlus
T107 Phosphorylation PhosphoSitePlus
N125 N-Glycosylation GlyGen 29741879
N215 N-Glycosylation GlyGen 29741879
T428 Phosphorylation PhosphoSitePlus
T431 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
K530 Acetylation PhosphoSitePlus
T533 Phosphorylation PhosphoSitePlus
K536 Acetylation PhosphoSitePlus
K536 Methylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
Y716 Phosphorylation PhosphoSitePlus
T770 Phosphorylation PhosphoSitePlus
Y774 Phosphorylation PhosphoSitePlus
S987 Phosphorylation PhosphoSitePlus
K1014 Acetylation PhosphoSitePlus
T1247 O-Glycosylation GlyGen 30459171
N1276 N-Glycosylation GlyGen 23090970, 29741879, 24190977
Site PTM Type PTM Enzyme Score Source PMID
S234 Phosphorylation HPRD 17081983
S236 Phosphorylation HPRD 17081983
S436 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T107 M107 Biomuta DOID:263 / kidney cancer [ tcga ]
T431 K431 Biomuta DOID:1324 / lung cancer [ cosmic ]
S987 R987 Biomuta DOID:3571 / liver cancer [ icgc ]