Protein Information

Cytoscape View


UniProt AC / UniProt ID P58340 / MLF1_HUMAN
Protein Name Myeloid leukemia factor 1
Gene Name Name: MLF1
Organism Homo sapiens (Human)

PRO ID PR:P58340
DAG View
PRO Name myeloid leukemia factor 1 (human)
Definition A myeloid leukemia factor 1 that is encoded in the genome of human.
Short Label hMLF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P58340 (MLF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus   UniProt 23186163
R23 Methylation PhosphoSitePlus
R27 Methylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus   UniProt 23186163
S34 Phosphorylation IntAct   PhosphoSitePlus   UniProt 22151054
R48 Methylation PhosphoSitePlus
R50 Methylation PhosphoSitePlus
Y85 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
K169 Acetylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
Y206 Phosphorylation PhosphoSitePlus
R219 Methylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P58340 (MLF1) S34 P62258 (YWHAE) unknown eFIP 22151054


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 R8 Biomuta DOID:363 / uterine cancer [ tcga ]
R23 * Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ icgc ] DOID:11054 / urinary bladder cancer [ tcga ]
R23 Q23 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R27 * Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K88 * Biomuta DOID:1319 / brain cancer [ icgc ]
R219 K219 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]