iPTMnet Report for P58005 (SESN3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P58005 / SESN3_HUMAN
Protein Name Sestrin-3
Gene Name Name: SESN3
Synonyms:SEST3;
Organism Homo sapiens (Human)

PRO ID PR:P58005
DAG View
PRO Name sestrin-3 (human)
Definition A sestrin-3 that is encoded in the genome of human.
Short Label hSESN3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P58005 (SESN3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R3 Methylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
R98 Methylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
T288 Phosphorylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
T447 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
Y455 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R98 C98 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
R98 H98 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ cosmic, icgc ]
R98 L98 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]