iPTMnet Report for P58004 (SESN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P58004 / SESN2_HUMAN
Protein Name Sestrin-2
Gene Name Name: SESN2
Synonyms:Hi95;
Organism Homo sapiens (Human)

PRO ID PR:P58004
DAG View
PRO Name sestrin-2 (human)
Definition A sestrin-2 that is encoded in the genome of human.
Short Label hSESN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P58004 (SESN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K13 Ubiquitination PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus   RLIMS-P 32854424
K158 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K175 Ubiquitination UniProt 35114100
S249 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S254 Phosphorylation PhosphoSitePlus   RLIMS-P 32854424
R274 Methylation PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
Y470 Phosphorylation HPRD   PhosphoSitePlus 18491316


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S73 C73 Biomuta DOID:3571 / liver cancer [ cosmic ]
K164 E164 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R274 W274 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y470 F470 Biomuta DOID:1324 / lung cancer [ cosmic ]