iPTMnet Report for P57081 (WDR4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P57081 / WDR4_HUMAN
Protein Name tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
Gene Name Name: WDR4
Organism Homo sapiens (Human)

PRO ID PR:P57081
DAG View
PRO Name tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (human)
Definition A tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 that is encoded in the genome of human.
Short Label hWDR4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P57081 (WDR4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K51 Ubiquitination PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
S391 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983
T409 Phosphorylation PhosphoSitePlus
S411 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
C412 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S391 Phosphorylation HPRD 17322306, 18767875, 19651622
S411 Phosphorylation HPRD 19413330, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S391 R391 Biomuta DOID:1319 / brain cancer [ cosmic ]
T409 M409 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]