iPTMnet Report for P57078 (RIPK4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P57078 / RIPK4_HUMAN
Protein Name Receptor-interacting serine/threonine-protein kinase 4
Gene Name Name: RIPK4
Synonyms:ANKRD3,DIK;
Organism Homo sapiens (Human)

PRO ID PR:P57078
DAG View
PRO Name receptor-interacting serine/threonine-protein kinase 4 (human)
Definition A receptor-interacting serine/threonine-protein kinase 4 that is encoded in the genome of human.
Short Label hRIPK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P57078 (RIPK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K51 Ubiquitination UniProt 21931591
S103 Phosphorylation IEDB 35494241
K145 Ubiquitination UniProt 21931591
S353 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
T521 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K51 N51 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K51 T51 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S103 F103 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S103 T103 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S420 L420 Biomuta DOID:4159 / skin cancer [ cosmic ]
T521 I521 Biomuta DOID:4159 / skin cancer [ cosmic ]