iPTMnet Report for P57073 (SOX8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P57073 / SOX8_HUMAN
Protein Name Transcription factor SOX-8
Gene Name Name: SOX8
Organism Homo sapiens (Human)

PRO ID PR:P57073
DAG View
PRO Name transcription factor SOX-8 (human)
Definition A transcription factor SOX-8 that is encoded in the genome of human.
Short Label hSOX8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P57073 (SOX8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K119 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K138 Acetylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
Y169 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
S327 Phosphorylation O14965 (AURKA) PhosphoSitePlus   RLIMS-P   Signor 32550913
S344 Phosphorylation IEDB   PhosphoSitePlus 27869121


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y169 D169 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S186 F186 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S188 L188 Biomuta DOID:363 / uterine cancer [ cosmic ]
T226 S226 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S327 A327 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S327 L327 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S344 R344 Biomuta DOID:10534 / stomach cancer [ cosmic ]