iPTMnet Report P57059 SIK1

Protein Information

UniProt AC / UniProt ID	P57059 / SIK1_HUMAN
Protein Name	Serine/threonine-protein kinase SIK1
Gene Name	Name: SIK1 Synonyms:SIK,SNF1LK;
Organism	Homo sapiens (Human)

PRO ID	PR:P57059 DAG View
PRO Name	serine/threonine-protein kinase SIK1 (human)
Definition	A serine/threonine-protein kinase SIK1 that is encoded in the genome of human.
Short Label	hSIK1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P57059 (SIK1) as Substrate

P57059

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine By position K20 T32 K42 K50 K56 K60 K70 K151 K175 T182 S186 T322 S370 S435 S437 T460 T473 T479 S516 S534 S575 T577 K584 K597 K604 S626 S634 S644	PTM Type Select all Phosphorylation Sumoylation Ubiquitination	PTM Enzyme Select all P49841 (GSK3B) P57059 (SIK1) Q14012 (CAMK1) Q15831 (STK11)	Score Select all 1 2 3 4	Source Select all HPRD IEDB PhosphoSitePlus RLIMS-P RLIMS-P+ Signor UniProt neXtProt phospho.ELM	PMID
K20	Sumoylation		score1	PhosphoSitePlus
K20	Ubiquitination		score1	PhosphoSitePlus
T32	Phosphorylation		score1	PhosphoSitePlus
K42	Ubiquitination		score1	PhosphoSitePlus
K50	Ubiquitination		score1	PhosphoSitePlus
K56	Ubiquitination		score1	PhosphoSitePlus
K60	Ubiquitination		score1	PhosphoSitePlus
K70	Ubiquitination		score1	PhosphoSitePlus
K151	Ubiquitination		score1	PhosphoSitePlus
K175	Sumoylation		score1	PhosphoSitePlus
K175	Ubiquitination		score1	PhosphoSitePlus
T182	Phosphorylation		score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P+ RLIMS-P Signor UniProt	33013689, 18946175, 14976552, ...18348280, 25384047
T182	Phosphorylation	P49841 (GSK3B)	score2	RLIMS-P+	18348280
T182	Phosphorylation	Q15831 (STK11)	score4	PhosphoSitePlus Signor	18946175, 14976552
S186	Phosphorylation		score3	neXtProt UniProt	18348280
S186	Phosphorylation	P57059 (SIK1)	score3	neXtProt UniProt	18348280
T322	Phosphorylation		score2	neXtProt	17939993
T322	Phosphorylation	Q14012 (CAMK1)	score2	neXtProt	17939993
S370	Phosphorylation		score1	PhosphoSitePlus
S435	Phosphorylation		score2	IEDB PhosphoSitePlus	27869121
S437	Phosphorylation		score1	PhosphoSitePlus
T460	Phosphorylation		score2	HPRD PhosphoSitePlus	17525332
T473	Phosphorylation		score3	PhosphoSitePlus UniProt	29211348
T479	Phosphorylation		score2	HPRD PhosphoSitePlus	17525332
S516	Phosphorylation		score1	PhosphoSitePlus
S534	Phosphorylation		score1	PhosphoSitePlus
S575	Phosphorylation		score4	neXtProt PhosphoSitePlus UniProt	29211348, 12200423
T577	Phosphorylation		score1	PhosphoSitePlus
K584	Sumoylation		score1	PhosphoSitePlus
K584	Ubiquitination		score1	PhosphoSitePlus
K597	Ubiquitination		score1	PhosphoSitePlus
K604	Sumoylation		score1	PhosphoSitePlus
K604	Ubiquitination		score1	PhosphoSitePlus
S626	Phosphorylation		score1	PhosphoSitePlus
S634	Phosphorylation		score1	PhosphoSitePlus
S644	Phosphorylation		score1	PhosphoSitePlus

P57059 (SIK1) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all P04637 (TP53) P10636 (MAPT) P36956 (SREBF1) P56524 (HDAC4) P57059 (SIK1) Q53ET0 (CRTC2) Q6UUV7 (CRTC3) Q6UUV9 (CRTC1) Q9UQL6 (HDAC5)	Site Select all By amino acid All Serine All Threonine By position S15 S62 S70 S151 S162 S167 S171 S186 S246 S259 S274 S306 S329 S337 S338 S348 S370 S402 S467 S498 T529 S531 S579 S610 S622 S641 S673	Score Select all 1 2 3 4	Source Select all HPRD Signor UniProt neXtProt	PMID
P04637 (TP53)	S15	score2	neXtProt	19622832
P10636 (MAPT)	T529	score2	neXtProt	21985311
P10636 (MAPT)	S531	score2	neXtProt	21985311
P10636 (MAPT)	S579	score2	neXtProt	21985311
P10636 (MAPT)	S610	score2	neXtProt	21985311
P10636 (MAPT)	S622	score2	neXtProt	21985311
P10636 (MAPT)	S641	score2	neXtProt	21985311
P10636 (MAPT)	S673	score2	neXtProt	21985311
P36956 (SREBF1)	S337	score2	neXtProt	19244231
P36956 (SREBF1)	S338	score2	neXtProt	19244231
P36956 (SREBF1)	S402	score2	neXtProt	19244231
P56524 (HDAC4)	S246	score2	neXtProt	17468767
P56524 (HDAC4)	S467	score2	neXtProt	17468767
P57059 (SIK1)	S186	score3	neXtProt UniProt	18348280
Q53ET0 (CRTC2)	S70	score3	HPRD Signor	16306228, 18669648
Q53ET0 (CRTC2)	S171	score4	HPRD neXtProt Signor	18348280, 20551288, 15454081, ...18669648, 16817901
Q53ET0 (CRTC2)	S274	score3	neXtProt	18348280, 20551288
Q53ET0 (CRTC2)	S306	score3	neXtProt	18348280, 20551288
Q53ET0 (CRTC2)	S348	score2	HPRD Signor	16306228
Q6UUV7 (CRTC3)	S62	score2	neXtProt	23033494
Q6UUV7 (CRTC3)	S162	score4	neXtProt Signor	23033494, 16817901
Q6UUV7 (CRTC3)	S329	score2	neXtProt	23033494
Q6UUV7 (CRTC3)	S370	score2	neXtProt	23033494
Q6UUV9 (CRTC1)	S151	score2	neXtProt	19244510
Q6UUV9 (CRTC1)	S167	score1	Signor	16817901
Q9UQL6 (HDAC5)	S259	score2	neXtProt	17468767
Q9UQL6 (HDAC5)	S498	score2	neXtProt	17468767

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position K60 K175 T182 S435 T460 T473 T479 S534 S634	Variant Select all F435 F534 M182 N634 P473 P479 R175 S460 T60	Source Select all Biomuta	Disease [Sample source] Select all DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:263 / kidney cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K60	T60	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K175	R175	Biomuta	DOID:263 / kidney cancer [ cosmic, icgc ]
T182	M182	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S435	F435	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T460	S460	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T473	P473	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
T479	P479	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S534	F534	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ icgc ]
S634	N634	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P57059 (SIK1)

Protein Information

Interactive Sequence View

P57059 (SIK1) as Substrate

P57059 (SIK1) as PTM Enzyme

PTM sites affected in variants