iPTMnet Report for P57059 (SIK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P57059 / SIK1_HUMAN
Protein Name Serine/threonine-protein kinase SIK1
Gene Name Name: SIK1
Synonyms:SIK,SNF1LK;
Organism Homo sapiens (Human)

PRO ID PR:P57059
DAG View
PRO Name serine/threonine-protein kinase SIK1 (human)
Definition A serine/threonine-protein kinase SIK1 that is encoded in the genome of human.
Short Label hSIK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P57059 (SIK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K20 Sumoylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K175 Sumoylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
T182 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 33013689, 18946175, 14976552, ...18348280, 25384047
T182 Phosphorylation P49841 (GSK3B) RLIMS-P+ 18348280
T182 Phosphorylation Q15831 (STK11) PhosphoSitePlus   Signor 18946175, 14976552
S186 Phosphorylation neXtProt   UniProt 18348280
S186 Phosphorylation P57059 (SIK1) neXtProt   UniProt 18348280
T322 Phosphorylation neXtProt 17939993
T322 Phosphorylation Q14012 (CAMK1) neXtProt 17939993
S370 Phosphorylation PhosphoSitePlus
S435 Phosphorylation IEDB   PhosphoSitePlus 27869121
S437 Phosphorylation PhosphoSitePlus
T460 Phosphorylation HPRD   PhosphoSitePlus 17525332
T473 Phosphorylation PhosphoSitePlus   UniProt 29211348
T479 Phosphorylation HPRD   PhosphoSitePlus 17525332
S516 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
S575 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 29211348, 12200423
T577 Phosphorylation PhosphoSitePlus
K584 Sumoylation PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
K604 Sumoylation PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
S626 Phosphorylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
S644 Phosphorylation PhosphoSitePlus


P57059 (SIK1) as PTM Enzyme



Substrate Site Score Source PMID
P04637 (TP53) S15 neXtProt 19622832
P10636 (MAPT) T529 neXtProt 21985311
P10636 (MAPT) S531 neXtProt 21985311
P10636 (MAPT) S579 neXtProt 21985311
P10636 (MAPT) S610 neXtProt 21985311
P10636 (MAPT) S622 neXtProt 21985311
P10636 (MAPT) S641 neXtProt 21985311
P10636 (MAPT) S673 neXtProt 21985311
P36956 (SREBF1) S337 neXtProt 19244231
P36956 (SREBF1) S338 neXtProt 19244231
P36956 (SREBF1) S402 neXtProt 19244231
P56524 (HDAC4) S246 neXtProt 17468767
P56524 (HDAC4) S467 neXtProt 17468767
P57059 (SIK1) S186 neXtProt   UniProt 18348280
Q53ET0 (CRTC2) S70 HPRD   Signor 16306228, 18669648
Q53ET0 (CRTC2) S171 HPRD   neXtProt   Signor 18348280, 20551288, 15454081, ...18669648, 16817901
Q53ET0 (CRTC2) S274 neXtProt 18348280, 20551288
Q53ET0 (CRTC2) S306 neXtProt 18348280, 20551288
Q53ET0 (CRTC2) S348 HPRD   Signor 16306228
Q6UUV7 (CRTC3) S62 neXtProt 23033494
Q6UUV7 (CRTC3) S162 neXtProt   Signor 23033494, 16817901
Q6UUV7 (CRTC3) S329 neXtProt 23033494
Q6UUV7 (CRTC3) S370 neXtProt 23033494
Q6UUV9 (CRTC1) S151 neXtProt 19244510
Q6UUV9 (CRTC1) S167 Signor 16817901
Q9UQL6 (HDAC5) S259 neXtProt 17468767
Q9UQL6 (HDAC5) S498 neXtProt 17468767