iPTMnet Report P56945 BCAR1

Protein Information

UniProt AC / UniProt ID	P56945 / BCAR1_HUMAN
Protein Name	Breast cancer anti-estrogen resistance protein 1
Gene Name	Name: BCAR1 Synonyms:CAS,CASS1,CRKAS;
Organism	Homo sapiens (Human)

PRO ID	PR:P56945 DAG View
PRO Name	breast cancer anti-estrogen resistance protein 1 (human)
Definition	A breast cancer anti-estrogen resistance protein 1 that is encoded in the genome of human.
Short Label	hBCAR1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P56945 (BCAR1) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position Y12 S18 Y67 S113 Y115 Y128 S134 S139 K143 Y165 Y179 S184 Y192 S202 Y222 Y224 Y234 Y249 S260 Y262 Y267 T269 Y287 S292 S300 Y306 S311 S313 T326 Y327 S355 Y362 Y372 T385 Y387 S407 Y410 S428 S430 S431 T432 S434 T435 S437 S438 S440 S602 S639 S648 Y653 Y664 Y666 K693 S694 K702 Y815 K831 K851	PTM Type Select all Acetylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3 4	Source Select all IntAct PRO PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
	Phosphorylation		score1	PRO
Y12	Phosphorylation	P51813 (BMX)	score4	PhosphoSitePlus RLIMS-P	23974298, 21937722, 28808245, ...24497348
S18	Phosphorylation		score1	PhosphoSitePlus
Y67	Phosphorylation		score1	PhosphoSitePlus
S113	Phosphorylation		score1	PhosphoSitePlus
Y115	Phosphorylation		score1	PhosphoSitePlus
Y128	Phosphorylation	P11362 (FGFR1) , P12931 (SRC)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	12601080, 11019781, 18083107, ...22710723, 16212419
S134	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 20068231
S139	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	19454314, 23186163, 16964243, ...18669648, 20068231
K143	Acetylation		score1	PhosphoSitePlus
Y165	Phosphorylation	Q13882 (PTK6) , Q07912 (TNK2)	score4	IntAct neXtProt phospho.ELM PRO PhosphoSitePlus Signor	22084245, 16247015, 15817476, ...17038317, 10889023
Y179	Phosphorylation		score1	PhosphoSitePlus
S184	Phosphorylation		score1	PhosphoSitePlus
Y192	Phosphorylation		score1	PhosphoSitePlus
S202	Phosphorylation		score1	PhosphoSitePlus
Y222	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	16212419
Y224	Phosphorylation	Q13882 (PTK6)	score4	neXtProt phospho.ELM PhosphoSitePlus	22084245, 16212419
Y234	Phosphorylation	Q13882 (PTK6)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus	18083107, 22084245, 16212419
Y249	Phosphorylation	Q13882 (PTK6) , P11362 (FGFR1) , P12931 (SRC) , Q07912 (TNK2)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor	12972425, 12601080, 25860930, ...22084245, 18083107, 16212419, 17038317, 16247015, 23874939
S260	Phosphorylation		score1	PhosphoSitePlus
Y262	Phosphorylation	Q13882 (PTK6)	score3	neXtProt PhosphoSitePlus	22084245
Y267	Phosphorylation	Q13882 (PTK6)	score3	neXtProt PRO PhosphoSitePlus	22084245
T269	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
Y287	Phosphorylation	Q13882 (PTK6)	score4	IntAct neXtProt PRO PhosphoSitePlus	22084245, 10889023
S292	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
S300	Phosphorylation		score1	PhosphoSitePlus
Y306	Phosphorylation	P11362 (FGFR1) , Q13882 (PTK6)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus Signor	22084245, 12601080
S311	Phosphorylation		score1	PhosphoSitePlus
S313	Phosphorylation		score1	PhosphoSitePlus
T326	Phosphorylation		score1	PhosphoSitePlus
Y327	Phosphorylation	P11362 (FGFR1) , Q13882 (PTK6)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus Signor	22084245, 12601080
S355	Phosphorylation		score1	PhosphoSitePlus
Y362	Phosphorylation	Q13882 (PTK6)	score3	neXtProt PRO PhosphoSitePlus	22084245
Y372	Phosphorylation		score2	PRO PhosphoSitePlus
T385	Phosphorylation		score1	PhosphoSitePlus
Y387	Phosphorylation	Q13882 (PTK6)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus	18083107, 15316024, 22084245, ...16212419
S407	Phosphorylation		score1	PhosphoSitePlus
Y410	Phosphorylation	Q05397 (PTK2) , P11362 (FGFR1) , Q07912 (TNK2)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor	16247015, 33042270, 12601080, ...25860930, 23716717, 23974298, 17038317, 23109808, 30639111, 28007913, 27293031
S428	Phosphorylation		score2	PhosphoSitePlus UniProt	21406692
S430	Phosphorylation		score1	PhosphoSitePlus
S431	Phosphorylation		score1	PhosphoSitePlus
T432	Phosphorylation		score1	PhosphoSitePlus
S434	Phosphorylation		score1	PhosphoSitePlus
T435	Phosphorylation		score1	PhosphoSitePlus
S437	Phosphorylation		score3	PhosphoSitePlus RLIMS-P UniProt	19454314
S438	Phosphorylation		score1	PhosphoSitePlus
S440	Phosphorylation		score1	PhosphoSitePlus
S602	Phosphorylation		score1	PhosphoSitePlus
S639	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	19454314, 23186163, 17081983
S648	Phosphorylation		score1	PhosphoSitePlus
Y653	Phosphorylation	P12931 (SRC)	score4	phospho.ELM PhosphoSitePlus	11604500, 12480533, 8670206
Y664	Phosphorylation	Q13882 (PTK6) , P12931 (SRC)	score4	IntAct neXtProt phospho.ELM PRO PhosphoSitePlus Signor	22084245, 8621540, 9360983, ...10542110, 11604500
Y666	Phosphorylation	P12931 (SRC)	score3	PRO PhosphoSitePlus Signor	11604500
K693	Ubiquitination		score1	PhosphoSitePlus
S694	Phosphorylation		score1	PhosphoSitePlus
K702	Ubiquitination		score1	PhosphoSitePlus
Y815	Phosphorylation		score1	PhosphoSitePlus
K831	Ubiquitination		score1	PhosphoSitePlus
K851	Ubiquitination		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position Y115 Y128 S134 S139 Y165 Y179 Y192 Y222 Y224 Y234 Y249 Y267 T269 Y287 S292 Y306 Y327 Y362 Y372 Y387 Y410 S428 S639 Y653 Y664 Y666	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 1 2	Source Select all HPRD	PMID
Y115	Phosphorylation	P12931 (SRC)	score1	HPRD	12972425
Y128	Phosphorylation		score2	HPRD	17016520, 19901323, 12601080, ...20068231
S134	Phosphorylation		score0	HPRD	18669648, 20068231
S139	Phosphorylation		score0	HPRD	18669648, 16964243, 20068231
Y165	Phosphorylation	P12931 (SRC)	score1	HPRD	12972425
Y179	Phosphorylation	P12931 (SRC)	score1	HPRD	12972425
Y192	Phosphorylation	P12931 (SRC)	score1	HPRD	12972425
Y222	Phosphorylation		score0	HPRD	16212419
Y224	Phosphorylation		score0	HPRD	16212419
Y234	Phosphorylation	P12931 (SRC)	score2	HPRD	12972425, 17016520, 17389395
Y249	Phosphorylation		score2	HPRD	17016520, 19901323, 12601080, ...20068231
Y267	Phosphorylation	P12931 (SRC)	score2	HPRD	12972425, 17016520, 17389395
T269	Phosphorylation		score0	HPRD	18669648
Y287	Phosphorylation	P12931 (SRC)	score2	HPRD	12972425, 17016520
S292	Phosphorylation		score0	HPRD	18669648
Y306	Phosphorylation		score1	HPRD	12601080
Y327	Phosphorylation		score2	HPRD	17016520, 17389395, 12601080
Y362	Phosphorylation	P12931 (SRC)	score2	HPRD	12972425, 17016520, 17389395
Y372	Phosphorylation		score0	HPRD	17016520
Y387	Phosphorylation	P12931 (SRC)	score2	HPRD	12972425, 17016520, 17389395, ...19901323
Y410	Phosphorylation		score2	HPRD	17016520, 17389395, 12601080
S428	Phosphorylation		score0	HPRD	20068231
S639	Phosphorylation		score0	HPRD	17081983
Y653	Phosphorylation	P12931 (SRC)	score1	HPRD	12972425
Y664	Phosphorylation	Q05397 (PTK2)	score2	HPRD	9360983, 9360968, 12119061
Y666	Phosphorylation	Q05397 (PTK2)	score1	HPRD	9360983

Search:

	Site Select all By amino acid All Threonine By position T15	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1	Source Select all PhosphoSitePlus	PMID
	T15	Phosphorylation		score1	PhosphoSitePlus

Search:

	Site Select all By amino acid All Serine By position S2 S18	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1	Source Select all PhosphoSitePlus	PMID
	S2	Phosphorylation		score1	PhosphoSitePlus
	S18	Phosphorylation		score1	PhosphoSitePlus

Proteoforms

Search:

PRO ID (Short Label) Select all PR:000046464 (hBCAR1/Phos:2) PR:000046465 (hBCAR1/Phos:3) PR:000046466 (hBCAR1/PhosTyr+)	Sites Select all p pY165,pY664 pY234,pY249,pY267,pY287,pY306,pY327,pY362,pY372,pY387,pY410,pY664,pY666	Source Select all PRO
PR:000046464 (hBCAR1/Phos:2)	pY165,pY664	PRO
PR:000046465 (hBCAR1/Phos:3)	pY234,pY249,pY267,pY287,pY306,pY327,pY362,pY372,pY387,pY410,pY664,pY666	PRO
PR:000046466 (hBCAR1/PhosTyr+)	p	PRO

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all P46108 (CRK) P56945 (BCAR1)	Site Select all By amino acid All Tyrosine By position Y12 Y221	Interactant Select all P56945 (BCAR1) Q05397 (PTK2)	Association type Select all decreased_association inhibited_association	Source Select all eFIP	PMID
	Phosphorylation	P46108 (CRK)	Y221	P56945 (BCAR1)	inhibited_association	eFIP	25860930
	Phosphorylation	P56945 (BCAR1)	Y12	Q05397 (PTK2)	decreased_association	eFIP	21937722

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S18 Y128 Y249 S260 Y287 Y306 S407 T432 S434 Y664 Y666	Variant Select all C128 C287 C664 C666 F18 G260 G434 H306 I432 N249 T407	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] [ cosmic ] [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S18	F18	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y128	C128	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
Y249	N249	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S260	G260	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
Y287	C287	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
Y306	H306	Biomuta	[ cosmic ] DOID:1115 / sarcoma [ icgc ]
S407	T407	Biomuta	DOID:1612 / breast cancer [ cosmic ]
T432	I432	Biomuta	[ cosmic ]
S434	G434	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y664	C664	Biomuta	DOID:3571 / liver cancer [ cosmic ]
Y666	C666	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P56945 (BCAR1)

Protein Information

Interactive Sequence View

P56945 (BCAR1) as Substrate

Proteoforms

PTM-dependent PPI

PTM sites affected in variants