iPTMnet Report for P56945 (BCAR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P56945 / BCAR1_HUMAN
Protein Name Breast cancer anti-estrogen resistance protein 1
Gene Name Name: BCAR1
Synonyms:CAS,CASS1,CRKAS;
Organism Homo sapiens (Human)

PRO ID PR:P56945
DAG View
PRO Name breast cancer anti-estrogen resistance protein 1 (human)
Definition A breast cancer anti-estrogen resistance protein 1 that is encoded in the genome of human.
Short Label hBCAR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P56945 (BCAR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Y12 Phosphorylation P51813 (BMX) PhosphoSitePlus   RLIMS-P 23974298, 21937722, 28808245, ...24497348
S18 Phosphorylation PhosphoSitePlus
Y67 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation P11362 (FGFR1) , P12931 (SRC) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12601080, 11019781, 18083107, ...22710723, 16212419
S134 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S139 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19454314, 23186163, 16964243, ...18669648, 20068231
K143 Acetylation PhosphoSitePlus
Y165 Phosphorylation Q13882 (PTK6) , Q07912 (TNK2) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 22084245, 16247015, 15817476, ...17038317, 10889023
Y179 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
Y192 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation phospho.ELM   PhosphoSitePlus 16212419
Y224 Phosphorylation Q13882 (PTK6) neXtProt   phospho.ELM   PhosphoSitePlus 22084245, 16212419
Y234 Phosphorylation Q13882 (PTK6) neXtProt   phospho.ELM   PRO   PhosphoSitePlus 18083107, 22084245, 16212419
Y249 Phosphorylation Q13882 (PTK6) , P11362 (FGFR1) , P12931 (SRC) , Q07912 (TNK2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 12972425, 12601080, 25860930, ...22084245, 18083107, 16212419, 17038317, 16247015, 23874939
S260 Phosphorylation PhosphoSitePlus
Y262 Phosphorylation Q13882 (PTK6) neXtProt   PhosphoSitePlus 22084245
Y267 Phosphorylation Q13882 (PTK6) neXtProt   PRO   PhosphoSitePlus 22084245
T269 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y287 Phosphorylation Q13882 (PTK6) IntAct   neXtProt   PRO   PhosphoSitePlus 22084245, 10889023
S292 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S300 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation P11362 (FGFR1) , Q13882 (PTK6) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 22084245, 12601080
S311 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
Y327 Phosphorylation P11362 (FGFR1) , Q13882 (PTK6) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 22084245, 12601080
S355 Phosphorylation PhosphoSitePlus
Y362 Phosphorylation Q13882 (PTK6) neXtProt   PRO   PhosphoSitePlus 22084245
Y372 Phosphorylation PRO   PhosphoSitePlus
T385 Phosphorylation PhosphoSitePlus
Y387 Phosphorylation Q13882 (PTK6) neXtProt   phospho.ELM   PRO   PhosphoSitePlus 18083107, 15316024, 22084245, ...16212419
S407 Phosphorylation PhosphoSitePlus
Y410 Phosphorylation Q05397 (PTK2) , P11362 (FGFR1) , Q07912 (TNK2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 16247015, 33042270, 12601080, ...25860930, 23716717, 23974298, 17038317, 23109808, 30639111, 28007913, 27293031
S428 Phosphorylation PhosphoSitePlus   UniProt 21406692
S430 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 19454314
S438 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus
S639 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19454314, 23186163, 17081983
S648 Phosphorylation PhosphoSitePlus
Y653 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus 11604500, 12480533, 8670206
Y664 Phosphorylation Q13882 (PTK6) , P12931 (SRC) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 22084245, 8621540, 9360983, ...10542110, 11604500
Y666 Phosphorylation P12931 (SRC) PRO   PhosphoSitePlus   Signor 11604500
K693 Ubiquitination PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
Y815 Phosphorylation PhosphoSitePlus
K831 Ubiquitination PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y115 Phosphorylation P12931 (SRC) HPRD 12972425
Y128 Phosphorylation HPRD 17016520, 19901323, 12601080, ...20068231
S134 Phosphorylation HPRD 18669648, 20068231
S139 Phosphorylation HPRD 18669648, 16964243, 20068231
Y165 Phosphorylation P12931 (SRC) HPRD 12972425
Y179 Phosphorylation P12931 (SRC) HPRD 12972425
Y192 Phosphorylation P12931 (SRC) HPRD 12972425
Y222 Phosphorylation HPRD 16212419
Y224 Phosphorylation HPRD 16212419
Y234 Phosphorylation P12931 (SRC) HPRD 12972425, 17016520, 17389395
Y249 Phosphorylation HPRD 17016520, 19901323, 12601080, ...20068231
Y267 Phosphorylation P12931 (SRC) HPRD 12972425, 17016520, 17389395
T269 Phosphorylation HPRD 18669648
Y287 Phosphorylation P12931 (SRC) HPRD 12972425, 17016520
S292 Phosphorylation HPRD 18669648
Y306 Phosphorylation HPRD 12601080
Y327 Phosphorylation HPRD 17016520, 17389395, 12601080
Y362 Phosphorylation P12931 (SRC) HPRD 12972425, 17016520, 17389395
Y372 Phosphorylation HPRD 17016520
Y387 Phosphorylation P12931 (SRC) HPRD 12972425, 17016520, 17389395, ...19901323
Y410 Phosphorylation HPRD 17016520, 17389395, 12601080
S428 Phosphorylation HPRD 20068231
S639 Phosphorylation HPRD 17081983
Y653 Phosphorylation P12931 (SRC) HPRD 12972425
Y664 Phosphorylation Q05397 (PTK2) HPRD 9360983, 9360968, 12119061
Y666 Phosphorylation Q05397 (PTK2) HPRD 9360983
Site PTM Type PTM Enzyme Score Source PMID
T15 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046464 (hBCAR1/Phos:2) pY165,pY664 PRO
PR:000046465 (hBCAR1/Phos:3) pY234,pY249,pY267,pY287,pY306,pY327,pY362,pY372,pY387,pY410,pY664,pY666 PRO
PR:000046466 (hBCAR1/PhosTyr+) p PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P46108 (CRK) Y221 P56945 (BCAR1) inhibited_association eFIP 25860930
Phosphorylation P56945 (BCAR1) Y12 Q05397 (PTK2) decreased_association eFIP 21937722


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S18 F18 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y128 C128 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y249 N249 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S260 G260 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y287 C287 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y306 H306 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S407 T407 Biomuta DOID:1612 / breast cancer [ cosmic ]
T432 I432 Biomuta [ cosmic ]
S434 G434 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y664 C664 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y666 C666 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]