iPTMnet Report for P56373 (P2RX3)
Protein Information
| UniProt AC / UniProt ID | P56373 / P2RX3_HUMAN |
| Protein Name | P2X purinoceptor 3 |
| Gene Name | Name: P2RX3 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P56373 |
| PRO Name | P2X purinoceptor 3 (human) |
| Definition | A P2X purinoceptor 3 that is encoded in the genome of human. |
| Short Label | hP2RX3 |
| Category | organism-gene |
DAG ViewP56373 (P2RX3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T134 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N139 | N-Glycosylation | score4 | GlyGen UniProt | 27626375, 21186285 | ||
| N170 | N-Glycosylation | score4 | GlyGen UniProt | 27626375, 21186285 | ||
| K176 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S178 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N194 | N-Glycosylation | score4 | GlyGen UniProt | 27626375, 21186285 | ||
| T196 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S269 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N290 | N-Glycosylation | score4 | GlyGen UniProt | 27626375, 21186285 | ||
| T388 | Phosphorylation | score0 | RLIMS-P | 24755854 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | P56373 (P2RX3) | T388 | Q03135 (CAV1) | increased_association | eFIP | 24755854 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| N139 | S139 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S178 | N178 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| N194 | I194 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| T388 | S388 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |
