Protein Information

Cytoscape View


UniProt AC / UniProt ID P56282 / DPOE2_HUMAN
Protein Name DNA polymerase epsilon subunit 2
Gene Name Name: POLE2
Synonyms:DPE2;
Organism Homo sapiens (Human)

PRO ID PR:P56282
DAG View
PRO Name DNA polymerase epsilon subunit 2 (human)
Definition A DNA polymerase epsilon subunit 2 that is encoded in the genome of human.
Short Label hPOLE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P56282 (POLE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K15 Ubiquitination PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
K191 Acetylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
Y465 Phosphorylation PhosphoSitePlus
Y467 Phosphorylation PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S508 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K44 E44 Biomuta DOID:363 / uterine cancer [ tcga ]
K105 T105 Biomuta DOID:1909 / melanoma [ cosmic ]
T122 K122 Biomuta DOID:3571 / liver cancer [ icgc ]
T122 I122 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]