iPTMnet Report for P56282 (POLE2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P56282 / DPOE2_HUMAN
Protein Name DNA polymerase epsilon subunit 2
Gene Name Name: POLE2
Synonyms:DPE2;
Organism Homo sapiens (Human)

PRO ID PR:P56282
DAG View
PRO Name DNA polymerase epsilon subunit 2 (human)
Definition A DNA polymerase epsilon subunit 2 that is encoded in the genome of human.
Short Label hPOLE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P56282 (POLE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K15 Ubiquitination PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
K191 Acetylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
C350 Methylation IEDB 31844290
C403 Methylation IEDB 31844290
K422 Ubiquitination PhosphoSitePlus
Y465 Phosphorylation PhosphoSitePlus
Y467 Phosphorylation PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S508 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K105 T105 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T122 I122 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K194 N194 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C403 S403 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
C403 R403 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K517 N517 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]