iPTMnet Report for P56211 (ARPP19)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P56211 / ARP19_HUMAN
Protein Name cAMP-regulated phosphoprotein 19
Gene Name Name: ARPP19
Organism Homo sapiens (Human)

PRO ID PR:P56211
DAG View
PRO Name cAMP-regulated phosphoprotein 19 (human)
Definition A cAMP-regulated phosphoprotein 19 that is encoded in the genome of human.
Short Label hARPP19
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P56211 (ARPP19) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163
S10 Phosphorylation PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus   UniProt 23186163
K26 Acetylation PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
K33 Acetylation PhosphoSitePlus
R35 Methylation PhosphoSitePlus
Y36 Phosphorylation PhosphoSitePlus
K42 Acetylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus   RLIMS-P 28613156
K55 Methylation PhosphoSitePlus
K58 Acetylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
Y59 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P 32085646, 33842550
Y65 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
T79 Phosphorylation PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S104 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 32085646, 11279279, 23186163, ...33842550
S108 Phosphorylation PhosphoSitePlus
K109 Acetylation PhosphoSitePlus   UniProt 19608861
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 20068231
T22 Phosphorylation HPRD 20068231
S23 Phosphorylation HPRD 20068231
S62 Phosphorylation HPRD 19413330, 18212344, 19664994, ...20058876, 20068231, 17924679
T79 Phosphorylation HPRD 20068231
S104 Phosphorylation HPRD 18212344
Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046397 (hARPP19/InitMet-/Phos:1) pS62 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P56211 (ARPP19) S46 Q15257 (PTPA) inhibited_association eFIP 28613156


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 I23 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K26 N26 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R35 K35 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K58 T58 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y59 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S104 P104 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S104 F104 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]