Protein Information

Cytoscape View


UniProt AC / UniProt ID P56192 / SYMC_HUMAN
Protein Name Methionine--tRNA ligase, cytoplasmic
Gene Name Name: MARS
Organism Homo sapiens (Human)

PRO ID PR:P56192
DAG View
PRO Name methionine--tRNA ligase, cytoplasmic (human)
Definition A methionine--tRNA ligase, cytoplasmic that is encoded in the genome of human.
Short Label hMARS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P56192 (MARS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S229 Phosphorylation Q9P2K8 (EIF2AK4) PhosphoSitePlus 22106287
K335 Ubiquitination PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
Y344 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K375 Acetylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
R376 Methylation PhosphoSitePlus
S472 Phosphorylation Q9P2K8 (EIF2AK4) PhosphoSitePlus 22106287
T482 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
Y549 Phosphorylation PhosphoSitePlus
S644 Phosphorylation PhosphoSitePlus
S662 Phosphorylation Q9P2K8 (EIF2AK4) PhosphoSitePlus   Signor 22106287
K663 Ubiquitination PhosphoSitePlus
T675 Phosphorylation PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
K726 Acetylation PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
K823 Ubiquitination PhosphoSitePlus
T824 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S825 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T833 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K838 Ubiquitination PhosphoSitePlus
K875 Ubiquitination PhosphoSitePlus
K881 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T824 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S825 Phosphorylation HPRD 19413330, 18669648
T833 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K335 T335 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S662 Y662 Biomuta DOID:363 / uterine cancer [ tcga ]
K823 Q823 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S825 P825 Biomuta DOID:4159 / skin cancer [ icgc ]