iPTMnet Report for P55957 (BID)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P55957 / BID_HUMAN
Protein Name BH3-interacting domain death agonist
Gene Name Name: BID
Organism Homo sapiens (Human)

PRO ID PR:P55957
DAG View
PRO Name BH3-interacting domain death agonist (human)
Definition A BH3-interacting domain death agonist that is encoded in the genome of human.
Short Label hBID
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P55957 (BID) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
Y54 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455
T59 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 11583622, 25760094, 25077544
T59 Phosphorylation P19784 (CSNK2A2) Signor 11583622
T59 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus 25077544
T59 Phosphorylation P45984 (MAPK9) neXtProt   PhosphoSitePlus 25077544
T59 Phosphorylation P48729 (CSNK1A1) Signor 11583622
T59 Phosphorylation P49674 (CSNK1E) Signor 11583622
T59 Phosphorylation P53779 (MAPK10) PhosphoSitePlus 25077544
T59 Phosphorylation P67870 (CSNK2B) Signor 11583622
T59 Phosphorylation P68400 (CSNK2A1) Signor 11583622
S64 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 11583622, 24767991
S64 Phosphorylation P19784 (CSNK2A2) Signor 11583622
S64 Phosphorylation P48729 (CSNK1A1) Signor 11583622
S64 Phosphorylation P49674 (CSNK1E) Signor 11583622
S64 Phosphorylation P67870 (CSNK2B) Signor 11583622
S64 Phosphorylation P68400 (CSNK2A1) Signor 11583622
S65 Phosphorylation RLIMS-P 24767991
S67 Phosphorylation PhosphoSitePlus   RLIMS-P 24767991
S76 Phosphorylation PhosphoSitePlus   RLIMS-P 25760094
S78 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 16122425, 17525332, 16122426
S78 Phosphorylation Q13315 (ATM) neXtProt 16122425, 16122426
S78 Phosphorylation Q13535 (ATR) neXtProt 16122426
K158 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y54 Phosphorylation HPRD 15592455, 17016520, 16497976
T59 Phosphorylation HPRD 11583622
T59 Phosphorylation P19784 (CSNK2A2) HPRD 11583622
T59 Phosphorylation P48729 (CSNK1A1) HPRD 11583622
T59 Phosphorylation P49674 (CSNK1E) HPRD 11583622
T59 Phosphorylation P67870 (CSNK2B) HPRD 11583622
T59 Phosphorylation P68400 (CSNK2A1) HPRD 11583622
S64 Phosphorylation HPRD 11583622
S64 Phosphorylation P19784 (CSNK2A2) HPRD 11583622
S64 Phosphorylation P48729 (CSNK1A1) HPRD 11583622
S64 Phosphorylation P49674 (CSNK1E) HPRD 11583622
S64 Phosphorylation P67870 (CSNK2B) HPRD 11583622
S64 Phosphorylation P68400 (CSNK2A1) HPRD 11583622
S78 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation HPRD 15592455, 17016520, 16497976
S124 Phosphorylation HPRD 17525332


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q03135 (CAV1) Y14 P55957 (BID) unknown eFIP 21382479


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:000028379 (hBID/iso:1/Clv:1) PRO 11583631


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y54 H54 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S64 C64 Biomuta DOID:3571 / liver cancer [ cosmic ]
S64 T64 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S67 P67 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y100 H100 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K158 R158 Biomuta DOID:1612 / breast cancer [ cosmic ]