Protein Information

Cytoscape View


UniProt AC / UniProt ID P55884 / EIF3B_HUMAN
Protein Name Eukaryotic translation initiation factor 3 subunit B
Gene Name Name: EIF3B
Synonyms:EIF3S9;
Organism Homo sapiens (Human)

PRO ID PR:P55884
DAG View
PRO Name eukaryotic translation initiation factor 3 subunit B (human)
Definition A eukaryotic translation initiation factor 3 subunit B that is encoded in the genome of human.
Short Label hEIF3B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P55884 (EIF3B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 22223895, 17322308
T68 Phosphorylation PhosphoSitePlus
S78 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S81 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S83 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 17322308, ...18220336
S85 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 17322308
S95 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S117 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S119 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17322308
S125 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 18669648, ...24275569, 17322308
R134 Phosphorylation PhosphoSitePlus
S152 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18669648, 20068231, ...19690332, 17322308
S154 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231, ...19690332, 17322308
S164 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17322308, 17081983, 20068231, ...19690332
K202 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K209 Acetylation PhosphoSitePlus   UniProt 19608861
K209 Ubiquitination PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
T218 Phosphorylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
T229 Phosphorylation PhosphoSitePlus
K230 Sumoylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
Y232 Phosphorylation PhosphoSitePlus
Y237 Phosphorylation PhosphoSitePlus
S239 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K248 Ubiquitination PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K288 Acetylation PhosphoSitePlus   UniProt 19608861
K288 Ubiquitination PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
Y339 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K364 Acetylation PhosphoSitePlus   UniProt 19608861
K364 Ubiquitination PhosphoSitePlus
T390 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
T397 Phosphorylation PhosphoSitePlus
R416 Methylation PhosphoSitePlus
K436 Acetylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
Y449 Phosphorylation PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
T500 Phosphorylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
Y525 Phosphorylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
T537 Phosphorylation PhosphoSitePlus
T542 Phosphorylation PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
K599 Ubiquitination PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
T710 Phosphorylation PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus
K729 Acetylation PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
K744 Acetylation PhosphoSitePlus
K744 Ubiquitination PhosphoSitePlus
T752 Phosphorylation PhosphoSitePlus
R758 Methylation PhosphoSitePlus
K762 Ubiquitination PhosphoSitePlus
Y768 Phosphorylation PhosphoSitePlus
K772 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S78 Phosphorylation HPRD 19413330, 18669648
S81 Phosphorylation HPRD 18669648
S83 Phosphorylation HPRD 18669648, 15302935, 19415658, ...20068231, 18452278
S85 Phosphorylation HPRD 19413330, 18669648, 18491316, ...15302935, 18452278
S95 Phosphorylation HPRD 18669648
S117 Phosphorylation HPRD 19651622, 20166139, 18669648, ...19664995
S119 Phosphorylation HPRD 17322306, 18669648, 19664995
S125 Phosphorylation HPRD 18669648, 15302935
S152 Phosphorylation HPRD 18491316, 17081983, 20058876, ...18452278, 18669648, 20068231, 18212344
S154 Phosphorylation HPRD 18491316, 18212344, 18452278, ...19415658, 20068231, 17081983
S164 Phosphorylation HPRD 18452278, 19415658, 20068231, ...17081983
S239 Phosphorylation HPRD 18669648, 20068231
T500 Phosphorylation HPRD 20068231
Y525 Phosphorylation HPRD 15592455
S728 Phosphorylation HPRD 20068231
S738 Phosphorylation HPRD 20068231


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025800 (hEIF3F/iso:1/Phos:1) increased Interaction PR:P55884 (hEIF3B) PRO 19245811


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S152 C152 Biomuta DOID:363 / uterine cancer [ tcga ]
K209 N209 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
Y232 C232 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y253 C253 Biomuta DOID:3070 / malignant glioma [ cosmic ]
K345 R345 Biomuta DOID:1909 / melanoma [ cosmic ]
K345 N345 Biomuta DOID:3571 / liver cancer [ icgc ]
T390 S390 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S447 R447 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
K463 N463 Biomuta DOID:1324 / lung cancer [ tcga ]
K529 E529 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K604 E604 Biomuta DOID:1909 / melanoma [ cosmic ]
K608 N608 Biomuta DOID:3571 / liver cancer [ icgc ]
R758 W758 Biomuta DOID:363 / uterine cancer [ tcga ]
K762 T762 Biomuta DOID:1324 / lung cancer [ tcga ]