iPTMnet Report for P55786 (NPEPPS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P55786 / PSA_HUMAN
Protein Name Puromycin-sensitive aminopeptidase
Gene Name Name: NPEPPS
Synonyms:PSA;
Organism Homo sapiens (Human)

PRO ID PR:P55786
DAG View
PRO Name puromycin-sensitive aminopeptidase (human)
Definition A puromycin-sensitive aminopeptidase that is encoded in the genome of human.
Short Label hNPEPPS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P55786 (NPEPPS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S30 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
K48 Acetylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
Y164 Phosphorylation PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
Y173 Phosphorylation PhosphoSitePlus
S203 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...34725712, 29351928, 34019948, 32870666, 32119511
K208 Ubiquitination PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
Y295 Phosphorylation PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K455 Acetylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
K459 Acetylation PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus
T466 Phosphorylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K563 Ubiquitination PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
S594 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
R615 Methylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
S684 Phosphorylation PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
K730 Ubiquitination PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
S745 Phosphorylation IEDB   PhosphoSitePlus 28228285
Y748 Phosphorylation PhosphoSitePlus
K776 Ubiquitination PhosphoSitePlus
T786 Phosphorylation PhosphoSitePlus
K829 Ubiquitination PhosphoSitePlus
K832 Acetylation PhosphoSitePlus
K832 Ubiquitination PhosphoSitePlus
K863 Ubiquitination PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus
S874 Phosphorylation PhosphoSitePlus
R900 Methylation PhosphoSitePlus
Y908 Phosphorylation PhosphoSitePlus
S915 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T199 Phosphorylation HPRD 20068231
T809 Phosphorylation HPRD 20068231
S820 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T165 A165 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T199 P199 Biomuta DOID:363 / uterine cancer [ icgc ]
K440 R440 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
K440 E440 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S594 C594 Biomuta DOID:1324 / lung cancer [ cosmic ]
R615 Q615 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S684 T684 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K719 N719 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S745 N745 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y748 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K832 R832 Biomuta DOID:1324 / lung cancer [ cosmic ]
R900 * Biomuta DOID:263 / kidney cancer [ cosmic ]
R900 Q900 Biomuta DOID:9256 / colorectal cancer [ cosmic ]