iPTMnet Report for P55265 (ADAR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P55265 / DSRAD_HUMAN
Protein Name Double-stranded RNA-specific adenosine deaminase
Gene Name Name: ADAR
Synonyms:ADAR1,DSRAD,G1P1,IFI4;
Organism Homo sapiens (Human)

PRO ID PR:P55265
DAG View
PRO Name double-stranded RNA-specific adenosine deaminase (human)
Definition A double-stranded RNA-specific adenosine deaminase that is encoded in the genome of human.
Short Label hADAR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P55265 (ADAR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R4 Methylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
T14 Phosphorylation PhosphoSitePlus
R26 Methylation PhosphoSitePlus   UniProt 24129315
K48 Methylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
S63 O-Glycosylation GlyGen 23301498, 27655845, 30444036, ...28510447, 32870666, 33214551, 30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 35083852, 31492838, 33465208, 35254053, 32119511, 35289036, 29351928, 34229054
R74 Methylation IEDB 27503676
R91 Methylation PhosphoSitePlus
R95 Methylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
R114 Methylation IEDB   PhosphoSitePlus 27503676
Y136 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
C304 Methylation IEDB 31844290
S311 O-Glycosylation GlyGen 33465208
S314 O-Glycosylation GlyGen 23301498, 27655845, 30444036, ...28510447, 32870666, 33214551, 30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 35083852, 31492838, 33465208, 35254053, 32119511, 35289036, 29351928, 34229054
K320 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
T349 Phosphorylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
K384 Sumoylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
T391 O-Glycosylation GlyGen 23301498, 27655845, 30444036, ...28510447, 32870666, 33214551, 30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 35083852, 31492838, 33465208, 35254053, 32119511, 35289036, 29351928, 34229054
T396 O-Glycosylation GlyGen 23301498, 27655845, 30444036, ...28510447, 32870666, 33214551, 30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 35083852, 31492838, 33465208, 35254053, 32119511, 35289036, 29351928, 34229054
S397 O-Glycosylation GlyGen 23301498, 27655845, 30444036, ...28510447, 32870666, 33214551, 30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 35083852, 31492838, 33465208, 35254053, 32119511, 35289036, 29351928, 34229054
S400 O-Glycosylation GlyGen 23301498, 27655845, 30444036, ...28510447, 32870666, 33214551, 30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 35083852, 31492838, 33465208, 35254053, 32119511, 35289036, 29351928, 34229054
K418 Sumoylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
Y438 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y483 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
K495 Acetylation PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
K558 Sumoylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
T567 Phosphorylation PhosphoSitePlus
K574 Acetylation PhosphoSitePlus
K574 Sumoylation PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
K576 Ubiquitination PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
K580 Sumoylation PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
Y587 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
K591 Ubiquitination PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
T596 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
T601 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T603 Phosphorylation PhosphoSitePlus   UniProt 23186163
S605 Phosphorylation PhosphoSitePlus
T607 Phosphorylation PhosphoSitePlus
S608 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S611 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K613 Ubiquitination PhosphoSitePlus
S614 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T617 Phosphorylation PhosphoSitePlus
T618 Phosphorylation PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
S629 O-Glycosylation GlyGen 23301498, 27655845, 30444036, ...28510447, 32870666, 33214551, 30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 35083852, 31492838, 33465208, 35254053, 32119511, 35289036, 29351928, 34229054
S629 Phosphorylation PhosphoSitePlus   UniProt 23186163
C630 Methylation IEDB 31844290
S636 Phosphorylation PhosphoSitePlus   UniProt 23186163
K637 Ubiquitination PhosphoSitePlus
Y648 Phosphorylation PhosphoSitePlus
T656 O-Glycosylation GlyGen 23301498, 27655845, 30444036, ...28510447, 32870666, 33214551, 30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 35083852, 31492838, 33465208, 35254053, 32119511, 35289036, 29351928, 34229054
K665 Acetylation PhosphoSitePlus
K665 Ubiquitination PhosphoSitePlus
K666 Acetylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K669 Sumoylation PhosphoSitePlus
K669 Ubiquitination PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
Y722 Phosphorylation PhosphoSitePlus
Y734 Phosphorylation PhosphoSitePlus
K745 Ubiquitination PhosphoSitePlus
K757 Acetylation PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
K781 Ubiquitination PhosphoSitePlus
K798 Acetylation PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
T808 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18220336, ...19690332, 20068231, 17924679
T811 O-Glycosylation GlyGen 23301498, 27655845, 30444036, ...28510447, 32870666, 33214551, 30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 35083852, 31492838, 33465208, 35254053, 32119511, 35289036, 29351928, 34229054
T811 Phosphorylation PhosphoSitePlus
S814 Phosphorylation PhosphoSitePlus   UniProt 23186163
T818 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S823 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S825 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
K831 Ubiquitination PhosphoSitePlus
C893 Methylation IEDB 31844290
K895 Ubiquitination PhosphoSitePlus
K902 Acetylation PhosphoSitePlus
K936 Ubiquitination PhosphoSitePlus
K944 Ubiquitination PhosphoSitePlus
K948 Ubiquitination PhosphoSitePlus
S975 Phosphorylation PhosphoSitePlus
S986 Phosphorylation PhosphoSitePlus
K996 Ubiquitination PhosphoSitePlus
K1003 Sumoylation PhosphoSitePlus
K1003 Ubiquitination PhosphoSitePlus
T1033 Phosphorylation PhosphoSitePlus
C1036 Methylation IEDB 31844290
S1089 Phosphorylation PhosphoSitePlus
R1096 Methylation PhosphoSitePlus
K1105 Acetylation PhosphoSitePlus
S1110 Phosphorylation PhosphoSitePlus
S1114 Phosphorylation PhosphoSitePlus
K1115 Acetylation PhosphoSitePlus
K1115 Ubiquitination PhosphoSitePlus
K1159 Acetylation PhosphoSitePlus
K1166 Acetylation PhosphoSitePlus
K1196 Ubiquitination PhosphoSitePlus
K1214 Ubiquitination PhosphoSitePlus
K1219 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T567 Phosphorylation HPRD 20068231
S599 Phosphorylation HPRD 19664995
T601 Phosphorylation HPRD 19413330, 18669648, 20058876, ...19664995, 20068231
S608 Phosphorylation HPRD 18669648
S611 Phosphorylation HPRD 18669648
S614 Phosphorylation HPRD 18669648, 20068231
T808 Phosphorylation HPRD 19413330, 17924679, 19664995, ...20068231, 16964243
T818 Phosphorylation HPRD 18669648, 17081983, 20068231
S823 Phosphorylation HPRD 18767875, 18669648, 20068231
S825 Phosphorylation HPRD 18691976, 18767875, 18452278, ...18669648, 20068231, 17924679
Site PTM Type PTM Enzyme Score Source PMID
T567 Phosphorylation HPRD 20068231
S599 Phosphorylation HPRD 19664995
T601 Phosphorylation HPRD 19413330, 18669648, 20058876, ...19664995, 20068231
S608 Phosphorylation HPRD 18669648
S611 Phosphorylation HPRD 18669648
S614 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T567 Phosphorylation HPRD 20068231
S599 Phosphorylation HPRD 19664995
T601 Phosphorylation HPRD 19413330, 18669648, 20058876, ...19664995, 20068231
S608 Phosphorylation HPRD 18669648
S611 Phosphorylation HPRD 18669648
S614 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T272 Phosphorylation HPRD 20068231
S304 Phosphorylation HPRD 19664995
T306 Phosphorylation HPRD 19413330, 18669648, 20058876, ...19664995, 20068231
S313 Phosphorylation HPRD 18669648
S316 Phosphorylation HPRD 18669648
S319 Phosphorylation HPRD 18669648, 20068231
T513 Phosphorylation HPRD 19413330, 17924679, 19664995, ...20068231, 16964243
T523 Phosphorylation HPRD 18669648, 17081983, 20068231
S528 Phosphorylation HPRD 18767875, 18669648, 20068231
S530 Phosphorylation HPRD 18691976, 18767875, 18452278, ...18669648, 20068231, 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R4 L4 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T14 S14 Biomuta DOID:3571 / liver cancer [ cosmic ]
R91 K91 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R95 S95 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R114 H114 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
K164 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y177 F177 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S217 N217 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K302 R302 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C304 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T349 I349 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y587 C587 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S599 F599 Biomuta DOID:4159 / skin cancer [ cosmic ]
S599 C599 Biomuta DOID:263 / kidney cancer [ cosmic ]
T601 P601 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S605 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K613 N613 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S629 P629 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S629 F629 Biomuta DOID:4159 / skin cancer [ cosmic ]
K669 E669 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S701 L701 Biomuta DOID:4159 / skin cancer [ cosmic ]
S707 T707 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S707 F707 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K715 T715 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T808 A808 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S823 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S825 F825 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K831 N831 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
K944 E944 Biomuta DOID:1324 / lung cancer [ cosmic ]
S975 F975 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S986 P986 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R1096 Q1096 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R1096 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1105 N1105 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1159 N1159 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K1219 N1219 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]