iPTMnet Report for P55196 (AFDN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P55196 / AFAD_HUMAN
Protein Name Afadin
Gene Name Name: AFDN
Synonyms:AF6,MLLT4;
Organism Homo sapiens (Human)

PRO ID PR:P55196
DAG View
PRO Name afadin (human)
Definition An afadin that is encoded in the genome of human.
Short Label hAFDN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P55196 (AFDN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y94 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T160 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
R178 Methylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
Y203 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S239 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus   UniProt 24275569
T249 Phosphorylation PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y263 Phosphorylation PhosphoSitePlus
Y295 Phosphorylation PhosphoSitePlus
Y375 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus   UniProt 23186163
T426 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus   UniProt 23186163
S551 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus   UniProt 23186163
S561 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus   UniProt 23186163
S564 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
T566 Phosphorylation PhosphoSitePlus
Y584 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus   UniProt 23186163
T591 O-Glycosylation GlyGen 23301498, 30379171, 34725712, ...35254053, 32119511, 28510447
S655 Phosphorylation PhosphoSitePlus   UniProt 23186163
S672 Phosphorylation PhosphoSitePlus
T909 Phosphorylation P11274 (BCR) PhosphoSitePlus 12808105
C960 Methylation IEDB 31844290
S973 Phosphorylation PhosphoSitePlus
T976 Phosphorylation PhosphoSitePlus
Y980 Phosphorylation PhosphoSitePlus
Y986 Phosphorylation PhosphoSitePlus
T995 Phosphorylation PhosphoSitePlus
T1009 O-Glycosylation GlyGen 23301498, 30379171, 34725712, ...35254053, 32119511, 28510447
T1011 Phosphorylation PhosphoSitePlus
K1014 Methylation PhosphoSitePlus
K1042 Ubiquitination PhosphoSitePlus
T1081 Phosphorylation PhosphoSitePlus
S1083 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1086 Phosphorylation PhosphoSitePlus
Y1096 Phosphorylation PhosphoSitePlus
T1101 Phosphorylation PhosphoSitePlus
S1107 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
R1117 Methylation PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
S1126 Phosphorylation PhosphoSitePlus
Y1132 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation PhosphoSitePlus
T1136 Phosphorylation PhosphoSitePlus
S1140 Phosphorylation PhosphoSitePlus
S1143 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1151 Phosphorylation PhosphoSitePlus
S1172 Phosphorylation PhosphoSitePlus
S1173 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1182 Phosphorylation PhosphoSitePlus   UniProt 23186163, 15144186, 18669648, ...24275569, 17693683, 19690332
K1186 Methylation PhosphoSitePlus
S1187 Phosphorylation PhosphoSitePlus
Y1189 Phosphorylation PhosphoSitePlus
S1191 Phosphorylation PhosphoSitePlus
T1194 Phosphorylation PhosphoSitePlus
S1199 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1201 Phosphorylation PhosphoSitePlus
T1202 Phosphorylation PhosphoSitePlus
T1207 Phosphorylation PhosphoSitePlus
T1211 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y1219 Phosphorylation PhosphoSitePlus
Y1226 Phosphorylation PhosphoSitePlus
Y1230 Phosphorylation PhosphoSitePlus
T1232 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S1236 Phosphorylation PhosphoSitePlus
S1238 O-Glycosylation GlyGen 23301498, 30379171, 34725712, ...35254053, 32119511, 28510447
S1238 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1252 Phosphorylation PhosphoSitePlus
S1265 Phosphorylation PhosphoSitePlus
S1266 Phosphorylation PhosphoSitePlus
S1275 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1285 Phosphorylation PhosphoSitePlus
S1300 Phosphorylation PhosphoSitePlus
S1302 Phosphorylation PhosphoSitePlus
S1328 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1330 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1333 Phosphorylation PhosphoSitePlus
T1334 Phosphorylation PhosphoSitePlus
T1352 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
Y1419 Phosphorylation PhosphoSitePlus
S1455 Phosphorylation PhosphoSitePlus
T1458 Phosphorylation PhosphoSitePlus
T1489 Phosphorylation PhosphoSitePlus
Y1497 Phosphorylation PhosphoSitePlus
T1499 Phosphorylation PhosphoSitePlus
S1501 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1506 Phosphorylation PhosphoSitePlus
S1512 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1573 O-Glycosylation GlyGen 23301498, 30379171, 34725712, ...35254053, 32119511, 28510447
Y1656 Phosphorylation PhosphoSitePlus
Y1657 Phosphorylation PhosphoSitePlus
S1658 Phosphorylation PhosphoSitePlus
Y1692 Phosphorylation PhosphoSitePlus
S1696 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1698 Phosphorylation PhosphoSitePlus
Y1714 Phosphorylation PhosphoSitePlus
K1716 Methylation PhosphoSitePlus
S1721 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S1772 Phosphorylation PhosphoSitePlus
S1774 Phosphorylation PhosphoSitePlus
S1779 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231
S1782 Phosphorylation PhosphoSitePlus
S1783 Phosphorylation PhosphoSitePlus
S1799 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
S1805 Phosphorylation PhosphoSitePlus
T1815 Phosphorylation PhosphoSitePlus
T1823 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y374 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y94 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
S533 Phosphorylation phospho.ELM 18669648
S1090 Phosphorylation PhosphoSitePlus
S1109 Phosphorylation PhosphoSitePlus
Y1213 Phosphorylation PhosphoSitePlus
Y1268 Phosphorylation PhosphoSitePlus
Y1480 Phosphorylation PhosphoSitePlus
Y1639 Phosphorylation PhosphoSitePlus
S1672 Phosphorylation PhosphoSitePlus
S1698 Phosphorylation PhosphoSitePlus
S1701 Phosphorylation PhosphoSitePlus
S1702 Phosphorylation PhosphoSitePlus
S1718 Phosphorylation PhosphoSitePlus
T1734 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y94 Phosphorylation HPRD 18083107
Y203 Phosphorylation HPRD 18707149
S216 Phosphorylation HPRD 19413330, 18669648, 19664994
S424 Phosphorylation HPRD 19664994
S561 Phosphorylation HPRD 18669648
S564 Phosphorylation HPRD 18669648
S565 Phosphorylation HPRD 18669648
S1083 Phosphorylation HPRD 19651622, 19664994, 19664995
S1107 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231
S1140 Phosphorylation HPRD 18452278
S1172 Phosphorylation HPRD 19413330, 19664995
S1173 Phosphorylation HPRD 19413330, 16964243, 19664995
S1182 Phosphorylation HPRD 19413330, 16964243, 18767875, ...19664994, 19664995, 19651622, 18669648, 17693683, 20166139
Y1230 Phosphorylation HPRD 17389395
T1232 Phosphorylation HPRD 18669648, 19664994
S1275 Phosphorylation HPRD 19651622, 20230923
S1317 Phosphorylation HPRD 18452278
T1330 Phosphorylation HPRD 19413330
S1512 Phosphorylation HPRD 19413330, 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y94 N94 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R178 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S181 F181 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y203 D203 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S216 A216 Biomuta DOID:4159 / skin cancer [ cosmic ]
S240 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S246 P246 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y295 H295 Biomuta DOID:4159 / skin cancer [ cosmic ]
S564 C564 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
Y980 C980 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y986 C986 Biomuta DOID:1612 / breast cancer [ cosmic, cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:363 / uterine cancer [ icgc, cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc, cosmic ] DOID:1319 / brain cancer [ cosmic ]
T1011 I1011 Biomuta DOID:1319 / brain cancer [ icgc ]
S1083 Y1083 Biomuta DOID:363 / uterine cancer [ icgc ]
S1109 C1109 Biomuta DOID:263 / kidney cancer [ cosmic ]
R1117 C1117 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S1126 C1126 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y1132 F1132 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1135 P1135 Biomuta DOID:1612 / breast cancer [ icgc ]
S1135 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T1202 S1202 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1211 M1211 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1236 F1236 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1252 C1252 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1268 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1275 F1275 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
S1275 Y1275 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y1285 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1300 F1300 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1489 M1489 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1506 T1506 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S1506 F1506 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1573 L1573 Biomuta DOID:363 / uterine cancer [ icgc ]
Y1639 H1639 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1656 H1656 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1672 Y1672 Biomuta DOID:363 / uterine cancer [ icgc ]
Y1692 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1698 L1698 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1701 G1701 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1718 A1718 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1772 F1772 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S1779 L1779 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1782 G1782 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1799 A1799 Biomuta DOID:4159 / skin cancer [ cosmic ]