Protein Information

Cytoscape View


UniProt AC / UniProt ID P55145 / MANF_HUMAN
Protein Name Mesencephalic astrocyte-derived neurotrophic factor precursor
Gene Name Name: MANF
Synonyms:ARMET,ARP;
Organism Homo sapiens (Human)

PRO ID PR:P55145
DAG View
PRO Name mesencephalic astrocyte-derived neurotrophic factor (human)
Definition A protein ARMET that is encoded in the genome of human.
Short Label hMANF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P55145 (MANF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
T129 Phosphorylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y121 H121 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K123 N123 Biomuta DOID:3571 / liver cancer [ icgc ]