iPTMnet Report for P55036 (PSMD4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P55036 / PSMD4_HUMAN
Protein Name 26S proteasome non-ATPase regulatory subunit 4
Gene Name Name: PSMD4
Synonyms:MCB1;
Organism Homo sapiens (Human)

PRO ID PR:P55036
DAG View
PRO Name 26S proteasome non-ATPase regulatory subunit 4 (human)
Definition A 26S proteasome non-ATPase regulatory subunit 4 that is encoded in the genome of human.
Short Label hPSMD4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P55036 (PSMD4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C9 S-Nitrosylation dbSNO 26338901
C37 Methylation IEDB 31844290
C37 S-Nitrosylation dbSNO 19483679
K40 Ubiquitination PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
C87 S-Nitrosylation dbSNO 19483679
K98 Ubiquitination PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
K122 Acetylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
S266 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 21406692, ...18669648, 20068231
Y326 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17323924
S361 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17323924
K365 Acetylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
K368 Acetylation PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S115 Phosphorylation HPRD 20068231
T250 Phosphorylation HPRD 15345747, 20068231
T253 Phosphorylation HPRD 20068231
S256 Phosphorylation HPRD 20068231
T264 Phosphorylation HPRD 20068231
S266 Phosphorylation HPRD 17525332, 18212344, 18077418, ...20058876, 18669648, 20166139, 20068231
S358 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K74 E74 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K81 N81 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K98 R98 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K133 R133 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K133 N133 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S242 F242 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T250 S250 Biomuta DOID:4159 / skin cancer [ cosmic ]
S358 F358 Biomuta DOID:4159 / skin cancer [ cosmic ]
K369 R369 Biomuta DOID:3571 / liver cancer [ cosmic ]