iPTMnet Report for P55011 (SLC12A2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P55011 / S12A2_HUMAN
Protein Name Solute carrier family 12 member 2
Gene Name Name: SLC12A2
Synonyms:NKCC1;
Organism Homo sapiens (Human)

PRO ID PR:P55011
DAG View
PRO Name solute carrier family 12 member 2 (human)
Definition A solute carrier family 12 member 2 that is encoded in the genome of human.
Short Label hSLC12A2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P55011 (SLC12A2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
S23 Phosphorylation PhosphoSitePlus
T75 Phosphorylation PhosphoSitePlus
S77 Phosphorylation P54646 (PRKAA2) , Q13131 (PRKAA1) phospho.ELM   PhosphoSitePlus   RLIMS-P+   UniProt 20442269, 18669648, 23186163, ...24702155
S79 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S87 Phosphorylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
T203 Phosphorylation Q9UEW8 (STK39) , O95747 (OXSR1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21423148, 16669787, 32413057, ...16382158, 12145304, 20091762, 27782176, 16950202
T207 Phosphorylation Q9UEW8 (STK39) , O95747 (OXSR1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21423148, 16669787, 16382158, ...20091762, 27782176, 16950202
Y208 Phosphorylation PhosphoSitePlus
T212 Phosphorylation Q9BYP7 (WNK3) , O95747 (OXSR1) , Q9UEW8 (STK39) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24702155, 21423148, 20091762, ...16275911, 16669787, 32413057, 16382158, 12145304, 12145305, 27782176, 16950202
T217 Phosphorylation Q9BYP7 (WNK3) , O95747 (OXSR1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 24702155, 23186163, 21423148, ...16275911, 32413057, 12145305
Y227 Phosphorylation PhosphoSitePlus
T230 Phosphorylation O95747 (OXSR1) PhosphoSitePlus 21423148
K237 Ubiquitination PhosphoSitePlus
S242 Phosphorylation P54646 (PRKAA2) PhosphoSitePlus   RLIMS-P+ 20442269
K252 Ubiquitination PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
T266 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T268 Phosphorylation PhosphoSitePlus
Y275 Phosphorylation PhosphoSitePlus
T276 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
Y353 Phosphorylation PhosphoSitePlus
N551 N-Glycosylation GlyGen 24190977
N553 N-Glycosylation GlyGen 29741879, 24190977
N562 N-Glycosylation GlyGen 24190977
K833 Methylation PhosphoSitePlus
K833 Ubiquitination PhosphoSitePlus
S836 Phosphorylation PhosphoSitePlus
K841 Ubiquitination PhosphoSitePlus
Y842 Phosphorylation PhosphoSitePlus
Y855 Phosphorylation PhosphoSitePlus
K923 Ubiquitination PhosphoSitePlus
S940 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
K943 Ubiquitination PhosphoSitePlus
S944 Phosphorylation PhosphoSitePlus
T947 Phosphorylation PhosphoSitePlus
K948 Ubiquitination PhosphoSitePlus
S953 Phosphorylation PhosphoSitePlus
Y956 Phosphorylation PhosphoSitePlus
S957 Phosphorylation PhosphoSitePlus
K958 Ubiquitination PhosphoSitePlus
K959 Ubiquitination PhosphoSitePlus
K966 Ubiquitination PhosphoSitePlus
K971 Ubiquitination PhosphoSitePlus
K976 Ubiquitination PhosphoSitePlus
K983 Ubiquitination PhosphoSitePlus
T984 Phosphorylation PhosphoSitePlus
K991 Ubiquitination PhosphoSitePlus
S994 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K995 Ubiquitination PhosphoSitePlus
K1007 Ubiquitination PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus
K1017 Ubiquitination PhosphoSitePlus
K1061 Ubiquitination PhosphoSitePlus
T1074 Phosphorylation PhosphoSitePlus
K1078 Ubiquitination PhosphoSitePlus
K1095 Ubiquitination PhosphoSitePlus
K1097 Ubiquitination PhosphoSitePlus
K1098 Sumoylation PhosphoSitePlus
K1098 Ubiquitination PhosphoSitePlus
K1118 Ubiquitination PhosphoSitePlus
K1125 Ubiquitination PhosphoSitePlus
K1127 Ubiquitination PhosphoSitePlus
K1143 Ubiquitination PhosphoSitePlus
Y1211 Phosphorylation PhosphoSitePlus
S1212 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S77 Phosphorylation HPRD 18669648
S79 Phosphorylation HPRD 18669648
T203 Phosphorylation O95747 (OXSR1) HPRD 16669787
T207 Phosphorylation O95747 (OXSR1) HPRD 16669787
T212 Phosphorylation O95747 (OXSR1) HPRD 16669787
S940 Phosphorylation HPRD 17525332
S994 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
K976 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S87 F87 Biomuta DOID:4159 / skin cancer [ cosmic ]
T207 I207 Biomuta DOID:1324 / lung cancer [ cosmic ]
T217 I217 Biomuta DOID:363 / uterine cancer [ cosmic ]
T266 A266 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y275 H275 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
N553 D553 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S836 P836 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K958 I958 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K966 I966 Biomuta DOID:184 / bone cancer [ cosmic ]
K995 R995 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1012 I1012 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1074 A1074 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K1097 T1097 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1097 N1097 Biomuta DOID:4362 / cervical cancer [ icgc ]
K1118 N1118 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1211 C1211 Biomuta DOID:9256 / colorectal cancer [ cosmic ]