Protein Information

Cytoscape View


UniProt AC / UniProt ID P54886 / P5CS_HUMAN
Protein Name Delta-1-pyrroline-5-carboxylate synthase
Gene Name Name: ALDH18A1
Synonyms:GSAS,P5CS,PYCS;
Organism Homo sapiens (Human)

PRO ID PR:P54886
DAG View
PRO Name delta-1-pyrroline-5-carboxylate synthase (human)
Definition A delta-1-pyrroline-5-carboxylate synthase that is encoded in the genome of human.
Short Label hALDH18A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54886 (ALDH18A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S79 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
K124 Methylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
K149 Acetylation PhosphoSitePlus
R212 Methylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K347 Acetylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
K409 Acetylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
T538 Phosphorylation PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
C606 S-Nitrosylation dbSNO 19483679
C612 S-Nitrosylation dbSNO 19483679
K643 Ubiquitination PhosphoSitePlus
K649 Acetylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
T725 Phosphorylation PhosphoSitePlus
R749 Methylation PhosphoSitePlus
T759 Phosphorylation PhosphoSitePlus
K761 Ubiquitination PhosphoSitePlus
K767 Acetylation PhosphoSitePlus
K767 Ubiquitination PhosphoSitePlus
S772 Phosphorylation PhosphoSitePlus
K781 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S103 Phosphorylation HPRD 20068231
S446 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S103 Phosphorylation HPRD 20068231
S444 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S79 G79 Biomuta DOID:363 / uterine cancer [ tcga ]
S143 L143 Biomuta DOID:1909 / melanoma [ tcga ]
K300 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T538 N538 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
C606 W606 Biomuta DOID:2531 / hematologic cancer [ icgc ]