iPTMnet Report for P54868 (HMGCS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P54868 / HMCS2_HUMAN
Protein Name Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor
Gene Name Name: HMGCS2
Organism Homo sapiens (Human)

PRO ID PR:P54868
DAG View
PRO Name hydroxymethylglutaryl-CoA synthase, mitochondrial (human)
Definition A hydroxymethylglutaryl-CoA synthase, mitochondrial that is encoded in the genome of human.
Short Label hHMGCS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54868 (HMGCS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
K83 Acetylation PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
Y250 Phosphorylation PhosphoSitePlus
K256 Acetylation PhosphoSitePlus
C261 Methylation IEDB 31844290
Y262 Phosphorylation PhosphoSitePlus
K276 Methylation PhosphoSitePlus
C305 S-Nitrosylation dbSNO 25040305
K310 Acetylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
T346 Phosphorylation PhosphoSitePlus
K366 Acetylation PhosphoSitePlus
K367 Acetylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus   UniProt 24275569
S440 Phosphorylation PhosphoSitePlus   UniProt 24275569
K447 Acetylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
K473 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T38 K38 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S248 L248 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S419 N419 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S433 C433 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
K473 R473 Biomuta DOID:1324 / lung cancer [ cosmic ]