iPTMnet Report for P54840 (GYS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P54840 / GYS2_HUMAN
Protein Name Glycogen [starch] synthase, liver
Gene Name Name: GYS2
Organism Homo sapiens (Human)

PRO ID PR:P54840
DAG View
PRO Name glycogen [starch] synthase, liver (human)
Definition A glycogen [starch] synthase, liver that is encoded in the genome of human.
Short Label hGYS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54840 (GYS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
S6 Phosphorylation PhosphoSitePlus
S8 Phosphorylation neXtProt   PhosphoSitePlus 22233421
S8 Phosphorylation Q13131 (PRKAA1) neXtProt 22233421
T10 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus
T50 Phosphorylation HPRD   PhosphoSitePlus 20068231
T203 Phosphorylation PhosphoSitePlus
K371 Acetylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K387 Acetylation PhosphoSitePlus
K397 Acetylation PhosphoSitePlus
Y405 Phosphorylation PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus   UniProt 24275569
S683 Phosphorylation PhosphoSitePlus   UniProt 24275569
S686 Phosphorylation PhosphoSitePlus
S688 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047664 (hGYS2/PhosSer+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 C6 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S8 C8 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T10 S10 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S11 F11 Biomuta DOID:4159 / skin cancer [ cosmic ]
K397 N397 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]