iPTMnet Report P54764 EPHA4

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P54764 / EPHA4_HUMAN
Protein Name	Ephrin type-A receptor 4 precursor
Gene Name	Name: EPHA4 Synonyms:HEK8,SEK,TYRO1;
Organism	Homo sapiens (Human)

PRO ID	PR:P54764 DAG View
PRO Name	ephrin type-A receptor 4 (human)
Definition	An ephrin type-A receptor 4 that is encoded in the genome of human.
Short Label	hEPHA4
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P54764 (EPHA4) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T117	Phosphorylation		score1	PhosphoSitePlus
	T168	Phosphorylation		score1	PhosphoSitePlus
	N235	N-Glycosylation		score1	GlyGen	23090970, 24190977
	S349	Phosphorylation		score1	PhosphoSitePlus
	S350	Phosphorylation		score1	PhosphoSitePlus
	T354	Phosphorylation		score1	PhosphoSitePlus
	T595	Phosphorylation		score1	PhosphoSitePlus
	Y596	Phosphorylation	P54764 (EPHA4)	score3	phospho.ELM PRO PhosphoSitePlus RLIMS-P	8622893
	T601	Phosphorylation		score1	PhosphoSitePlus
	Y602	Phosphorylation	P54764 (EPHA4)	score3	phospho.ELM PRO PhosphoSitePlus RLIMS-P	8622893
	S637	Phosphorylation		score1	PhosphoSitePlus
	K693	Acetylation		score1	PhosphoSitePlus
	K735	Ubiquitination		score1	PhosphoSitePlus
	S741	Phosphorylation		score1	PhosphoSitePlus
	Y779	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P	18083107, 26376612
	T781	Phosphorylation		score1	PhosphoSitePlus
	Y798	Phosphorylation		score1	PhosphoSitePlus
	S887	Phosphorylation		score1	PhosphoSitePlus
	T957	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y596	Phosphorylation	P54764 (EPHA4)	score1	HPRD	8622893
	Y602	Phosphorylation	P54764 (EPHA4)	score1	HPRD	8622893

P54764 (EPHA4) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	P19174 (PLCG1)	Y783	score2	neXtProt	17494698
	P54764 (EPHA4)	Y596	score3	HPRD phospho.ELM PhosphoSitePlus	8622893
	P54764 (EPHA4)	Y602	score3	HPRD phospho.ELM PhosphoSitePlus	8622893
	Q00535 (CDK5)	Y15	score2	neXtProt	17143272

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000047296 (hEPHA4/SigPep-/Phos:1)	pY596,pY602		PRO

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
T595	K595	Biomuta		DOID:3571 / liver cancer [ cosmic ]
T601	M601	Biomuta		DOID:1612 / breast cancer [ cosmic ]
K735	T735	Biomuta		DOID:10534 / stomach cancer [ cosmic ]