Protein Information

Cytoscape View


UniProt AC / UniProt ID P54762 / EPHB1_HUMAN
Protein Name Ephrin type-B receptor 1 precursor
Gene Name Name: EPHB1
Synonyms:ELK,EPHT2,HEK6,NET;
Organism Homo sapiens (Human)

PRO ID PR:P54762
DAG View
PRO Name ephrin type-B receptor 1 (human)
Definition An ephrin type-B receptor 1 that is encoded in the genome of human.
Short Label hEPHB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54762 (EPHB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T92 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
N477 N-Glycosylation GlyGen 24190977
N480 N-Glycosylation GlyGen 24190977
Y575 Phosphorylation PhosphoSitePlus
Y582 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
Y594 Phosphorylation IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 32368295, 9430661, 23181695
T599 Phosphorylation PhosphoSitePlus
Y600 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 15951569
Y634 Phosphorylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
Y740 Phosphorylation PhosphoSitePlus
S754 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
S766 Phosphorylation PhosphoSitePlus
Y768 Phosphorylation PhosphoSitePlus
S774 Phosphorylation PhosphoSitePlus
T777 Phosphorylation PhosphoSitePlus
Y778 Phosphorylation phospho.ELM   PhosphoSitePlus 12925710
Y798 Phosphorylation PhosphoSitePlus
Y928 Phosphorylation PhosphoSitePlus
S968 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y594 Phosphorylation P54762 (EPHB1) HPRD 17389395, 10669731
Y600 Phosphorylation HPRD 17016520, 15951569
Y928 Phosphorylation P54762 (EPHB1) HPRD 8798570


P54762 (EPHB1) as PTM Enzyme



Substrate Site Score Source PMID
P54762-1 (EPHB1) Y594 HPRD 17389395, 10669731
P54762-1 (EPHB1) Y928 HPRD 8798570
Q8WXD9 (CASKIN1) Y296 neXtProt 23181695
Q8WXD9 (CASKIN1) Y336 neXtProt 23181695
Q92823 (NRCAM) Y1276 neXtProt   Signor 24023801


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047304 (hEPHB1/SigPep-/Phos:1) pY594,pY600 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P54762 (EPHB1) Y594 P16333 (NCK1) unknown eFIP 9430661
Phosphorylation P54762 (EPHB1) Y594 Q99M51 (Nck1) unknown eFIP 9430661


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S395 C395 Biomuta DOID:1324 / lung cancer [ tcga ]
N480 S480 Biomuta DOID:1324 / lung cancer [ tcga ]
Y575 F575 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S583 I583 Biomuta DOID:3571 / liver cancer [ icgc ]
S588 F588 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y594 C594 Biomuta DOID:4362 / cervical cancer [ tcga ]
Y594 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T599 S599 Biomuta DOID:3571 / liver cancer [ icgc ]
K643 N643 Biomuta DOID:1909 / melanoma [ cosmic ] DOID:11934 / head and neck cancer [ tcga ]
Y740 H740 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S766 F766 Biomuta DOID:263 / kidney cancer [ tcga ]
Y768 * Biomuta DOID:1324 / lung cancer [ tcga ]
Y778 F778 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S968 I968 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]