iPTMnet Report for P54760 (EPHB4)
Protein Information
| UniProt AC / UniProt ID | P54760 / EPHB4_HUMAN |
| Protein Name | Ephrin type-B receptor 4 precursor |
| Gene Name | Name: EPHB4 Synonyms:HTK,MYK1,TYRO11; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P54760 |
| PRO Name | ephrin type-B receptor 4 (human) |
| Definition | An ephrin type-B receptor 4 that is encoded in the genome of human. |
| Short Label | hEPHB4 |
| Category | organism-gene |
DAG ViewP54760 (EPHB4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T34 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K196 | Acetylation | score1 | PhosphoSitePlus | |||
| N203 | N-Glycosylation | score1 | GlyGen | 23090970, 29741879, 24190977 | ||
| T321 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T322 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S332 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N335 | N-Glycosylation | score1 | GlyGen | 23090970, 24190977 | ||
| S337 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y357 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K474 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T544 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y574 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S575 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K577 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y581 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T587 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y590 | Phosphorylation | score2 | PRO PhosphoSitePlus | |||
| T595 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y596 | Phosphorylation | score2 | PRO PhosphoSitePlus | |||
| K608 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y614 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K640 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K647 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K650 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T713 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S750 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S757 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S762 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S769 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S770 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| T773 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y774 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T775 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S776 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S777 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K781 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S872 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K885 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y906 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S911 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 19369195 | ||
| Y924 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S943 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| T953 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K960 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S964 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K973 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T976 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 18669648, 23186163, ... | ||
| T980 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y987 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 19369195, 31270394 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y574 | Phosphorylation | score0 | HPRD | 17016520 | ||
| Y590 | Phosphorylation | score0 | HPRD | 17016520, 20068231 | ||
| T595 | Phosphorylation | score0 | HPRD | 20068231 | ||
| Y596 | Phosphorylation | score0 | HPRD | 17016520, 20068231 | ||
| S769 | Phosphorylation | score0 | HPRD | 18691976, 18578522, 20068231 | ||
| Y774 | Phosphorylation | score0 | HPRD | 18691976, 17389395 | ||
| Y906 | Phosphorylation | score0 | HPRD | 17016520 | ||
| S911 | Phosphorylation | score0 | HPRD | 18691976 | ||
| T953 | Phosphorylation | score0 | HPRD | 18691976 | ||
| T976 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 18669648 |
P54760 (EPHB4) as PTM Enzyme
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000047309 (hEPHB4/SigPep-/Phos:1) | pY590,pY596 | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T322 | S322 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| S332 | F332 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| K474 | N474 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
| T544 | M544 | Biomuta | DOID:1319 / brain cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] | |
| S575 | L575 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y581 | C581 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| T587 | A587 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
| K640 | T640 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| K640 | N640 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| T775 | M775 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S777 | F777 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| K781 | N781 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
| S943 | F943 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
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