iPTMnet Report for P54750 (PDE1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P54750 / PDE1A_HUMAN
Protein Name Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Gene Name Name: PDE1A
Organism Homo sapiens (Human)

PRO ID PR:P54750
DAG View
PRO Name dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human)
Definition A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A that is encoded in the genome of human.
Short Label hPDE1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54750 (PDE1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K53 Ubiquitination PhosphoSitePlus
Y58 Phosphorylation PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
T86 Phosphorylation PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y282 Phosphorylation HPRD 19664995
Site PTM Type PTM Enzyme Score Source PMID
Y282 Phosphorylation HPRD 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T71 K71 Biomuta DOID:3571 / liver cancer [ cosmic ]
T71 A71 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T185 P185 Biomuta DOID:1324 / lung cancer [ cosmic ]
T185 I185 Biomuta DOID:4159 / skin cancer [ cosmic ]
T185 A185 Biomuta DOID:1324 / lung cancer [ cosmic ]
S198 Y198 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S403 F403 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S487 Y487 Biomuta DOID:263 / kidney cancer [ cosmic ]
S487 F487 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]