iPTMnet Report for P54578 (USP14)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P54578 / UBP14_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 14
Gene Name Name: USP14
Synonyms:TGT;
Organism Homo sapiens (Human)

PRO ID PR:P54578
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 14 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 14 that is encoded in the genome of human.
Short Label hUSP14
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54578 (USP14) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y4 Phosphorylation PhosphoSitePlus
K14 Acetylation PhosphoSitePlus
K49 Acetylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
T52 Phosphorylation PhosphoSitePlus   UniProt 23186163
K54 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 26523394, 21406692, 23186163, ...19367720, 24275569, 19690332, 20068231
S148 Phosphorylation PhosphoSitePlus
Y151 Phosphorylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus   RLIMS-P 26523394
S232 Phosphorylation PhosphoSitePlus
T235 Phosphorylation P06493 (CDK1) PhosphoSitePlus   RLIMS-P   UniProt 26523394, 18234856, 20068231, ...24275569
S237 Phosphorylation PhosphoSitePlus   UniProt 23186163
K238 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
S241 Phosphorylation RLIMS-P 27884201
K269 Ubiquitination PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
K284 Acetylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
Y285 Phosphorylation PhosphoSitePlus
K291 Acetylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
R293 Methylation PhosphoSitePlus
T299 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S302 O-Glycosylation GlyGen 29351928, 28510447, 26853435, ...30397120
S302 Phosphorylation PhosphoSitePlus   UniProt 23186163
T304 O-Glycosylation GlyGen 29351928, 28510447, 26853435, ...30397120
K313 Acetylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K391 Acetylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
Y417 Phosphorylation PhosphoSitePlus
S432 Phosphorylation P31749 (AKT1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 26523394, 31740976, 23186163
Y436 Phosphorylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K449 Acetylation PhosphoSitePlus   UniProt 19608861
K449 Ubiquitination PhosphoSitePlus
K454 Acetylation PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y136 Phosphorylation HPRD 18669648
S143 Phosphorylation HPRD 18767875, 19664995, 19651622, ...18669648, 20166139, 20068231
T235 Phosphorylation HPRD 18669648, 20068231
Y285 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
Y101 Phosphorylation HPRD 18669648
S108 Phosphorylation HPRD 18767875, 19664995, 19651622, ...18669648, 20166139, 20068231
T200 Phosphorylation HPRD 18669648, 20068231
Y250 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K14 Q14 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K54 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S83 L83 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K134 R134 Biomuta DOID:3571 / liver cancer [ tcga ]
K214 I214 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
S222 Y222 Biomuta DOID:363 / uterine cancer [ tcga ]
S230 F230 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
K239 N239 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S241 R241 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
R293 Q293 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]
R293 * Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
S302 Y302 Biomuta DOID:1909 / melanoma [ cosmic ]
T304 M304 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K342 R342 Biomuta DOID:5041 / esophageal cancer [ tcga ]
K373 Q373 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K375 T375 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K375 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K381 * Biomuta DOID:363 / uterine cancer [ tcga ]
K400 N400 Biomuta DOID:3571 / liver cancer [ icgc ]
K443 Q443 Biomuta DOID:1612 / breast cancer [ tcga ]
K449 N449 Biomuta DOID:3571 / liver cancer [ icgc ]
K454 E454 Biomuta DOID:0070003 / blastoma [ cosmic ]
K454 T454 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]