Protein Information

Cytoscape View


UniProt AC / UniProt ID P54289 / CA2D1_HUMAN
Protein Name Voltage-dependent calcium channel subunit alpha-2/delta-1 precursor
Gene Name Name: CACNA2D1
Synonyms:CACNL2A,CCHL2A,MHS3;
Organism Homo sapiens (Human)

PRO ID PR:P54289
DAG View
PRO Name voltage-dependent calcium channel subunit alpha-2/delta-1 (human)
Definition A voltage-dependent calcium channel subunit alpha-2/delta-1 that is encoded in the genome of human.
Short Label hCACNA2D1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54289 (CACNA2D1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S52 Phosphorylation PhosphoSitePlus
N136 N-Glycosylation GlyGen 23090970, 24190977
Y217 Phosphorylation PhosphoSitePlus
Y218 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
Y236 Phosphorylation PhosphoSitePlus
N324 N-Glycosylation GlyGen 23090970, 29741879, 29391424, ...24190977
N348 N-Glycosylation GlyGen 29391424
N675 N-Glycosylation GlyGen 29391424
N781 N-Glycosylation GlyGen 29671580
N824 N-Glycosylation GlyGen 29391424
N888 N-Glycosylation GlyGen 29391424
S989 Phosphorylation PhosphoSitePlus
N1042 N-Glycosylation GlyGen 29391424
Site PTM Type PTM Enzyme Score Source PMID
K530 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S52 N52 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S52 R52 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y218 D218 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S227 N227 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
N324 I324 Biomuta DOID:1324 / lung cancer [ tcga ]
N348 I348 Biomuta DOID:363 / uterine cancer [ tcga ]
N1042 S1042 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]