iPTMnet Report for P54289 (CACNA2D1)
Protein Information
| UniProt AC / UniProt ID | P54289 / CA2D1_HUMAN |
| Protein Name | Voltage-dependent calcium channel subunit alpha-2/delta-1 precursor |
| Gene Name | Name: CACNA2D1 Synonyms:CACNL2A,CCHL2A,MHS3; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P54289 |
| PRO Name | voltage-dependent calcium channel subunit alpha-2/delta-1 (human) |
| Definition | A voltage-dependent calcium channel subunit alpha-2/delta-1 that is encoded in the genome of human. |
| Short Label | hCACNA2D1 |
| Category | organism-gene |
DAG ViewP54289 (CACNA2D1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S52 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N92 | N-Glycosylation | score3 | GlyGen UniProt | 34234349 | ||
| N136 | N-Glycosylation | score1 | GlyGen | 23090970, 24190977 | ||
| N184 | N-Glycosylation | score3 | GlyGen UniProt | 34234349 | ||
| Y217 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y218 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S227 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y236 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N324 | N-Glycosylation | score1 | GlyGen | 23090970, 29741879, 29391424, ... | ||
| N348 | N-Glycosylation | score4 | GlyGen UniProt | 29391424, 34234349 | ||
| N468 | N-Glycosylation | score3 | GlyGen UniProt | 34234349 | ||
| N613 | N-Glycosylation | score3 | GlyGen UniProt | 34234349 | ||
| N675 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
| N781 | N-Glycosylation | score4 | GlyGen UniProt | 29671580, 34234349 | ||
| N824 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
| N888 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
| N895 | N-Glycosylation | score3 | GlyGen UniProt | 34234349 | ||
| T935 | Phosphorylation | score1 | IEDB | 35494241 | ||
| S989 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N1042 | N-Glycosylation | score1 | GlyGen | 29391424 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K530 | Acetylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S52 | N52 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| S52 | R52 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| N184 | K184 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| Y218 | D218 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
| S227 | N227 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] | |
| N324 | I324 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S989 | L989 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S989 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| N1042 | S1042 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] |
