Protein Information

Cytoscape View


UniProt AC / UniProt ID P54274 / TERF1_HUMAN
Protein Name Telomeric repeat-binding factor 1
Gene Name Name: TERF1
Synonyms:PIN2,TRBF1,TRF,TRF1;
Organism Homo sapiens (Human)

PRO ID PR:P54274
DAG View
PRO Name telomeric repeat-binding factor 1 (human)
Definition A telomeric repeat-binding factor 1 that is encoded in the genome of human.
Short Label hTERF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54274 (TERF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 20068231
S7 Phosphorylation PhosphoSitePlus
S11 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S114 Phosphorylation Q8TDX7 (NEK7) PhosphoSitePlus   RLIMS-P+ 28216227
T122 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P   Signor 18347021
K136 Ubiquitination PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
S219 Phosphorylation Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11375976, 17717821
K241 Acetylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
T273 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus 19160102
K295 Acetylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
K300 Acetylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
T330 Phosphorylation PhosphoSitePlus   RLIMS-P 31273934, 29097657
T344 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus   RLIMS-P 18625707, 21712819
S347 Phosphorylation PhosphoSitePlus
T358 Phosphorylation PhosphoSitePlus
S367 Phosphorylation Q13315 (ATM) PhosphoSitePlus   RLIMS-P+ 22266654
T371 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus   RLIMS-P 23997120, 18625707, 21712819, ...27185864
K397 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
S434 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S435 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18625707, 18669648
S437 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD 19413330, 17081983, 20068231
S219 Phosphorylation Q13315 (ATM) HPRD 11375976
S434 Phosphorylation HPRD 18669648
S435 Phosphorylation HPRD 18669648
S437 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD 19413330, 17081983, 20068231
S219 Phosphorylation Q13315 (ATM) HPRD 11375976
S414 Phosphorylation HPRD 18669648
S415 Phosphorylation HPRD 18669648
S417 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T122 M122 Biomuta DOID:363 / uterine cancer [ tcga ]
K241 N241 Biomuta DOID:1324 / lung cancer [ cosmic ]
K241 R241 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S253 * Biomuta DOID:1324 / lung cancer [ tcga ]
S347 I347 Biomuta DOID:3571 / liver cancer [ icgc ]
S434 F434 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S434 C434 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]