iPTMnet Report for P54253 (ATXN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P54253 / ATX1_HUMAN
Protein Name Ataxin-1
Gene Name Name: ATXN1
Synonyms:ATX1,SCA1;
Organism Homo sapiens (Human)

PRO ID PR:P54253
DAG View
PRO Name ataxin-1 (human)
Definition An ataxin-1 that is encoded in the genome of human.
Short Label hATXN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54253 (ATXN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K16 Sumoylation PhosphoSitePlus
T22 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...31492838, 29351928, 35132862, 35289036, 35254053, 28657654
S23 O-Glycosylation GlyGen 33214551, 32574038, 35132862, ...30620550, 34019948, 31492838, 29351928, 35289036, 35254053, 28657654
R53 Methylation PhosphoSitePlus
S82 O-Glycosylation GlyGen 33214551, 32574038, 35132862, ...30620550, 34019948, 31492838, 29351928, 35289036, 35254053, 28657654, 29237092
S82 Phosphorylation PhosphoSitePlus
T83 O-Glycosylation GlyGen 32574038
S88 O-Glycosylation GlyGen 34846842, 33214551, 32574038, ...34019948, 29351928, 35132862, 31492838, 35289036, 35254053, 28657654
S88 Phosphorylation PhosphoSitePlus   UniProt 23186163
S91 O-Glycosylation GlyGen 34846842, 33214551, 32574038, ...34019948, 29351928, 35132862, 31492838, 35289036, 35254053, 28657654
S91 Phosphorylation PhosphoSitePlus
K194 Sumoylation PhosphoSitePlus
T235 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus   UniProt 18669648
Y247 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
T524 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...31492838, 29351928, 35132862, 35289036, 35254053, 28657654
K609 Sumoylation PhosphoSitePlus
K696 Sumoylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
K745 Sumoylation PhosphoSitePlus
T769 Phosphorylation PhosphoSitePlus
S775 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 12741986, 17540008, 12757707, ...23719381, 20477910
S775 Phosphorylation O75582 (RPS6KA5) PhosphoSitePlus 23719381
S775 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 20477910
S775 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 12757707, 17540008
S811 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S238 Phosphorylation HPRD 18669648, 20068231
S251 Phosphorylation HPRD 20068231
S253 Phosphorylation HPRD 18669648
T595 Phosphorylation HPRD 20068231
S775 Phosphorylation HPRD 12741986, 12757707
S775 Phosphorylation P31749 (AKT1) HPRD 12741986, 12757707


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S88 F88 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y247 H247 Biomuta DOID:363 / uterine cancer [ cosmic ]
S253 F253 Biomuta DOID:4159 / skin cancer [ cosmic ]
S312 N312 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T769 M769 Biomuta DOID:4159 / skin cancer [ cosmic ]