iPTMnet Report for P54252 (ATXN3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P54252 / ATX3_HUMAN
Protein Name Ataxin-3
Gene Name Name: ATXN3
Synonyms:ATX3,MJD,MJD1,SCA3;
Organism Homo sapiens (Human)

PRO ID PR:P54252
DAG View
PRO Name ataxin-3 (human)
Definition An ataxin-3 that is encoded in the genome of human.
Short Label hATXN3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54252 (ATXN3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
Y58 Phosphorylation PhosphoSitePlus
T60 Phosphorylation PhosphoSitePlus
K117 Sumoylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K166 Sumoylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus   UniProt 23696636
K206 Ubiquitination PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S256 Phosphorylation P49841 (GSK3B) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17434145
S260 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 31379806
T269 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
K360 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K117 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S236 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 19542537
S265 Phosphorylation HPRD 18077418
S335 Phosphorylation P68400 (CSNK2A1) neXtProt   PhosphoSitePlus 19542537
S347 Phosphorylation P68400 (CSNK2A1) neXtProt   PhosphoSitePlus 19542537
Site PTM Type PTM Enzyme Score Source PMID
S210 Phosphorylation HPRD 18077418


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14757 (CHEK1) S345 P54252 (ATXN3) unknown eFIP 28180282


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T60 M60 Biomuta DOID:363 / uterine cancer [ cosmic ]
K117 T117 Biomuta DOID:363 / uterine cancer [ icgc ]
K206 I206 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S210 F210 Biomuta DOID:3571 / liver cancer [ cosmic ]
S256 R256 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S265 F265 Biomuta DOID:3571 / liver cancer [ cosmic ]
S347 P347 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S347 Y347 Biomuta DOID:10534 / stomach cancer [ cosmic ]