iPTMnet Report for P54198 (HIRA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P54198 / HIRA_HUMAN
Protein Name Protein HIRA
Gene Name Name: HIRA
Synonyms:DGCR1,HIR,TUPLE1;
Organism Homo sapiens (Human)

PRO ID PR:P54198
DAG View
PRO Name protein HIRA (human)
Definition A protein HIRA that is encoded in the genome of human.
Short Label hHIRA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54198 (HIRA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K27 Ubiquitination PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus   UniProt 23186163
K114 Acetylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
S231 O-Glycosylation GlyGen 27217568, 35254053
K259 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
S310 O-Glycosylation GlyGen 27217568, 35254053
K381 Ubiquitination PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
S425 O-Glycosylation GlyGen 27217568, 35254053
S533 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
S543 O-Glycosylation GlyGen 27217568, 35254053
S543 Phosphorylation PhosphoSitePlus
T544 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S551 Phosphorylation PhosphoSitePlus
T554 Phosphorylation PhosphoSitePlus
T555 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11238922
T555 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   Signor 11238922
S557 Phosphorylation PhosphoSitePlus   UniProt 19690332
S567 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
T576 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
T583 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18847512
T583 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S584 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18847512
S584 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T586 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18847512, 18669648, ...19690332, 20068231
T586 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T588 Phosphorylation PhosphoSitePlus 18847512
T588 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K594 Ubiquitination PhosphoSitePlus
K600 Acetylation PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
S610 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S611 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648
S612 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648
S614 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648
T637 Phosphorylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus   RLIMS-P 27515126
S656 Phosphorylation PhosphoSitePlus
S658 Phosphorylation PhosphoSitePlus
S661 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S675 Phosphorylation PhosphoSitePlus   UniProt 23186163
S687 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 11238922
S697 Phosphorylation PhosphoSitePlus
T711 Phosphorylation PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
K754 Ubiquitination PhosphoSitePlus
S812 Phosphorylation PhosphoSitePlus
S815 Phosphorylation PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
S876 O-Glycosylation GlyGen 27217568, 35254053
Y945 Phosphorylation PhosphoSitePlus
Y953 Phosphorylation PhosphoSitePlus
K988 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T393 Phosphorylation HPRD 19562805
S538 Phosphorylation HPRD 19413330
S549 Phosphorylation HPRD 19413330, 18452278
S551 Phosphorylation HPRD 19413330
T555 Phosphorylation HPRD 19413330, 11238922
T555 Phosphorylation P24941 (CDK2) HPRD 19413330, 11238922
S557 Phosphorylation HPRD 19413330
T576 Phosphorylation HPRD 18669648
T583 Phosphorylation HPRD 18669648, 20068231
S584 Phosphorylation HPRD 18669648, 19664995, 20068231
T586 Phosphorylation HPRD 19651622, 18669648, 19664995, ...20068231
S610 Phosphorylation HPRD 18669648, 20068231, 18452278
S611 Phosphorylation HPRD 18669648, 20068231
S612 Phosphorylation HPRD 18669648, 20068231
S614 Phosphorylation HPRD 18669648, 20068231, 18452278
S661 Phosphorylation HPRD 18669648, 19664995, 20068231
S687 Phosphorylation HPRD 11238922, 20068231
S687 Phosphorylation P24941 (CDK2) HPRD 11238922, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K114 N114 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K279 I279 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K279 Q279 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T393 I393 Biomuta DOID:263 / kidney cancer [ cosmic ]
S611 N611 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S656 F656 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S675 C675 Biomuta DOID:1612 / breast cancer [ cosmic ]
K988 N988 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]