iPTMnet Report for P54136 (RARS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P54136 / SYRC_HUMAN
Protein Name Arginine--tRNA ligase, cytoplasmic
Gene Name Name: RARS1
Synonyms:RARS;
Organism Homo sapiens (Human)

PRO ID PR:P54136
DAG View
PRO Name arginine--tRNA ligase, cytoplasmic (human)
Definition An arginine--tRNA ligase, cytoplasmic that is encoded in the genome of human.
Short Label hRARS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54136 (RARS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895
K20 Ubiquitination PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
T103 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
K143 Methylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
C150 S-Nitrosylation dbSNO 26338901
K193 Ubiquitination PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
K205 Acetylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
T215 Phosphorylation PhosphoSitePlus
Y230 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
R279 Methylation PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
K287 Acetylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus
C293 Methylation IEDB 31844290
K300 Ubiquitination PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
Y338 Phosphorylation PhosphoSitePlus
R341 Methylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
R352 Methylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
C369 S-Nitrosylation dbSNO 19483679
S370 Phosphorylation PhosphoSitePlus
K377 Acetylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
Y384 Phosphorylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
K451 Acetylation PhosphoSitePlus
K453 Acetylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
R472 Methylation PhosphoSitePlus
Y516 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
Y536 Phosphorylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K563 Ubiquitination PhosphoSitePlus
K570 Acetylation PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
C598 Methylation IEDB 31844290
K655 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation HPRD 19413330
T282 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K20 Q20 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S105 N105 Biomuta DOID:1319 / brain cancer [ icgc ]
S200 Y200 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y230 C230 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R279 G279 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R279 W279 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
R341 T341 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R472 Q472 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S519 F519 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K563 N563 Biomuta DOID:363 / uterine cancer [ icgc ]