iPTMnet Report for P54132 (BLM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P54132 / BLM_HUMAN
Protein Name RecQ-like DNA helicase BLM
Gene Name Name: BLM
Synonyms:RECQ2,RECQL3;
Organism Homo sapiens (Human)

PRO ID PR:P54132
DAG View
PRO Name RecQ-like DNA helicase BLM (human)
Definition A RecQ-like DNA helicase BLM that is encoded in the genome of human.
Short Label hBLM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54132 (BLM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO 20719863
S17 Phosphorylation PhosphoSitePlus
T20 Phosphorylation PhosphoSitePlus
K24 Sumoylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S28 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K31 Sumoylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus
K38 Methylation PhosphoSitePlus
K39 Methylation PhosphoSitePlus
K40 Sumoylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
S48 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19007248, 19691289
T50 Phosphorylation PhosphoSitePlus
S53 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K56 Sumoylation PhosphoSitePlus
T57 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T68 Phosphorylation PhosphoSitePlus
S72 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S74 Phosphorylation PhosphoSitePlus
K91 Sumoylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
T99 Phosphorylation Q13535 (ATR) , Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 14729972, 16199871, 12034743, ...11375976, 25766002
K105 Sumoylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
T114 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T122 Phosphorylation Q13535 (ATR) , Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 25766002, 14729972, 12034743
T125 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19691289
T127 Phosphorylation PhosphoSitePlus
K129 Sumoylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S142 Phosphorylation HPRD   phospho.ELM 18669648
S143 Phosphorylation HPRD   PhosphoSitePlus 20068231
S144 Phosphorylation P33981 (TTK) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 16864798, 20068231, ...18452278
K167 Ubiquitination PhosphoSitePlus
S168 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
T171 Phosphorylation P49841 (GSK3B) HPRD   PhosphoSitePlus   UniProt 26028025, 23186163, 20068231
S175 Phosphorylation P24941 (CDK2) PhosphoSitePlus 26028025
T182 Phosphorylation O96017 (CHEK2) , O14757 (CHEK1) PhosphoSitePlus 26028025
K195 Methylation PhosphoSitePlus
K195 Sumoylation PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
S282 Phosphorylation HPRD   PhosphoSitePlus 19651622, 19007248, 19691289
Y296 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus   RLIMS-P 25794620
K317 Sumoylation PRO   PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
S328 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
K331 Sumoylation PRO   PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
S336 Phosphorylation HPRD 20068231
T337 Phosphorylation HPRD 20068231
S338 Phosphorylation Q8NG66 (NEK11) HPRD   PhosphoSitePlus   RLIMS-P   UniProt 25794620, 23186163, 24239288, ...20068231
K339 Ubiquitination PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
K344 Sumoylation PRO   PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K347 Sumoylation PRO   PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
S358 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19691289
T359 Phosphorylation HPRD 19691289
S367 Phosphorylation PhosphoSitePlus
C380 Methylation IEDB 31844290
K390 Ubiquitination PhosphoSitePlus
K392 Sumoylation PhosphoSitePlus
K409 Sumoylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
T412 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
K418 Sumoylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
S419 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 16565220
S422 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...16565220
S426 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S434 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
S462 Phosphorylation HPRD   PhosphoSitePlus 20068231
S464 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
T473 Phosphorylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
S480 Phosphorylation HPRD   PhosphoSitePlus 19007248, 17924679
K484 Sumoylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K498 Sumoylation PhosphoSitePlus
S499 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 19690332
S502 Phosphorylation PhosphoSitePlus
T508 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16964243
K514 Sumoylation PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
T537 Phosphorylation PhosphoSitePlus
S539 Phosphorylation O14757 (CHEK1) HPRD   PhosphoSitePlus 21851590, 19691289, 20068231
S550 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y551 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K578 Ubiquitination PhosphoSitePlus
S579 Phosphorylation HPRD 19007248
K588 Sumoylation PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
K594 Sumoylation PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
S601 Phosphorylation HPRD   PhosphoSitePlus 19691289
K604 Ubiquitination PhosphoSitePlus
S612 O-Glycosylation GlyGen 32938750
K629 Ubiquitination PhosphoSitePlus
N633 N-Glycosylation GlyGen 24190977
S646 Phosphorylation O14757 (CHEK1) , PR:O14757 (hCHEK1) PRO   PhosphoSitePlus   RLIMS-P   Signor 20719863
K653 Ubiquitination PhosphoSitePlus
K657 Acetylation PhosphoSitePlus
K661 Acetylation PhosphoSitePlus
K662 Acetylation PhosphoSitePlus
K662 Sumoylation PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
Y699 Phosphorylation PhosphoSitePlus
S714 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus   RLIMS-P 16880735
Y736 Phosphorylation PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
K755 Ubiquitination PhosphoSitePlus
T766 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus   RLIMS-P 16880735
K769 Ubiquitination PhosphoSitePlus
S773 Phosphorylation PhosphoSitePlus
C799 Methylation IEDB 31844290
K820 Sumoylation PhosphoSitePlus
K820 Ubiquitination PhosphoSitePlus
T830 Phosphorylation PhosphoSitePlus
T832 Phosphorylation PhosphoSitePlus
K839 Sumoylation PhosphoSitePlus
K839 Ubiquitination PhosphoSitePlus
K863 Acetylation PhosphoSitePlus   UniProt 19608861
K863 Ubiquitination PhosphoSitePlus
K873 Sumoylation PhosphoSitePlus
K873 Ubiquitination PhosphoSitePlus
T903 Phosphorylation PhosphoSitePlus
T907 Phosphorylation PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
K1082 Sumoylation PhosphoSitePlus
K1082 Ubiquitination PhosphoSitePlus
S1083 Phosphorylation PhosphoSitePlus
K1125 Sumoylation PhosphoSitePlus
K1125 Ubiquitination PhosphoSitePlus
K1133 Ubiquitination PhosphoSitePlus
S1197 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1199 Sumoylation PhosphoSitePlus
K1199 Ubiquitination PhosphoSitePlus
K1207 Ubiquitination PhosphoSitePlus
K1217 Ubiquitination PhosphoSitePlus
K1273 Sumoylation PhosphoSitePlus
K1273 Ubiquitination PhosphoSitePlus
S1280 Phosphorylation PhosphoSitePlus
S1290 Phosphorylation P33981 (TTK) PhosphoSitePlus 16864798
S1295 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18452278
S1296 Phosphorylation P33981 (TTK) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16864798, 15302935, 18452278, ...18669648, 20068231
S1303 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1304 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1310 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18452278
K1329 Ubiquitination PhosphoSitePlus
K1372 Sumoylation PhosphoSitePlus
K1372 Ubiquitination PhosphoSitePlus
S1375 Phosphorylation PhosphoSitePlus
S1383 Phosphorylation PhosphoSitePlus
K1411 Acetylation PhosphoSitePlus
S1417 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045543 (hBLM/Phos:1) p PRO 20719863
PR:000045543 (hBLM/Phos:1) pS646 PR:O14757 (hCHEK1) PRO 20719863
PR:000046485 (hBLM/Sumo:1) suK317,suK331,suK344,suK347 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P54132 (BLM) S304 Q92547 (TOPBP1) unknown eFIP 25794620


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K31 N31 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S33 L33 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
K39 N39 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S48 C48 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S48 F48 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T50 S50 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S53 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S72 F72 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
T125 P125 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S131 P131 Biomuta DOID:1324 / lung cancer [ cosmic ]
S144 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S144 L144 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S168 L168 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S175 I175 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K225 N225 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y296 F296 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S304 Y304 Biomuta DOID:363 / uterine cancer [ icgc ]
K323 R323 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S328 C328 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S343 L343 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K347 N347 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C380 S380 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T412 M412 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K418 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S426 L426 Biomuta DOID:4159 / skin cancer [ cosmic ]
S449 C449 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S449 Y449 Biomuta DOID:363 / uterine cancer [ icgc ]
S456 L456 Biomuta DOID:4159 / skin cancer [ cosmic ]
S462 Y462 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S480 F480 Biomuta DOID:4159 / skin cancer [ cosmic ]
K484 N484 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K535 Q535 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T537 S537 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y551 C551 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S579 F579 Biomuta DOID:4159 / skin cancer [ cosmic ]
S579 Y579 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S601 Y601 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
N633 H633 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ]
S646 G646 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K653 N653 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K653 M653 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y736 C736 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K741 N741 Biomuta DOID:363 / uterine cancer [ icgc ]
T830 M830 Biomuta [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
K839 E839 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K873 N873 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T907 M907 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
K1057 I1057 Biomuta DOID:11615 / penile cancer [ cosmic ]
S1280 L1280 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1290 L1290 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]