Protein Information

Cytoscape View

UniProt AC / UniProt ID P54132 / BLM_HUMAN
Protein Name Bloom syndrome protein
Gene Name Name: BLM
Organism Homo sapiens (Human)

PRO ID PR:P54132
DAG View
PRO Name Bloom syndrome protein (human)
Definition A Bloom syndrome protein that is encoded in the genome of human.
Short Label hBLM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P54132 (BLM) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO 20719863
S17 Phosphorylation PhosphoSitePlus
T20 Phosphorylation PhosphoSitePlus
K24 Sumoylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S28 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K31 Sumoylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus
K38 Methylation PhosphoSitePlus
K39 Methylation PhosphoSitePlus
K40 Sumoylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
S48 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19007248, 19691289
T50 Phosphorylation PhosphoSitePlus
S53 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K56 Sumoylation PhosphoSitePlus
T57 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T68 Phosphorylation PhosphoSitePlus
S72 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S74 Phosphorylation PhosphoSitePlus
K91 Sumoylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
T99 Phosphorylation Q13535 (ATR) , Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11375976, 16199871, 14729972, ...12034743
K105 Sumoylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
T114 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T122 Phosphorylation Q13535 (ATR) , Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus 14729972, 12034743
T125 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19691289
T127 Phosphorylation PhosphoSitePlus
K129 Sumoylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S142 Phosphorylation HPRD   phospho.ELM 18669648
S143 Phosphorylation HPRD   PhosphoSitePlus 20068231
S144 Phosphorylation P33981 (TTK) HPRD   phospho.ELM   PhosphoSitePlus 18669648, 16864798, 20068231, ...18452278
K167 Ubiquitination PhosphoSitePlus
S168 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
T171 Phosphorylation P49841 (GSK3B) HPRD   PhosphoSitePlus   UniProt 26028025, 23186163, 20068231
S175 Phosphorylation P24941 (CDK2) PhosphoSitePlus 26028025
T182 Phosphorylation O96017 (CHEK2) , O14757 (CHEK1) PhosphoSitePlus 26028025
K195 Methylation PhosphoSitePlus
K195 Sumoylation PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
S282 Phosphorylation HPRD   PhosphoSitePlus 19651622, 19007248, 19691289
Y296 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
K317 Sumoylation PRO   PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
S328 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
K331 Sumoylation PRO   PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
S336 Phosphorylation HPRD 20068231
T337 Phosphorylation HPRD 20068231
S338 Phosphorylation Q8NG66 (NEK11) HPRD   PhosphoSitePlus   UniProt 23186163, 24239288, 20068231
K339 Ubiquitination PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
K344 Sumoylation PRO   PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K347 Sumoylation PRO   PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
S358 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19691289
T359 Phosphorylation HPRD 19691289
S367 Phosphorylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
K392 Sumoylation PhosphoSitePlus
K409 Sumoylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
T412 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
K418 Sumoylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
S419 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 16565220
S422 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...16565220
S426 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S434 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
S462 Phosphorylation HPRD   PhosphoSitePlus 20068231
S464 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
T473 Phosphorylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
S480 Phosphorylation HPRD   PhosphoSitePlus 19007248, 17924679
K484 Sumoylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K498 Sumoylation PhosphoSitePlus
S499 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 19690332
S502 Phosphorylation PhosphoSitePlus
T508 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16964243
K514 Sumoylation PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
T537 Phosphorylation PhosphoSitePlus
S539 Phosphorylation O14757 (CHEK1) HPRD   PhosphoSitePlus 21851590, 19691289, 20068231
S550 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y551 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K578 Ubiquitination PhosphoSitePlus
S579 Phosphorylation HPRD 19007248
K588 Sumoylation PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
K594 Sumoylation PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
S601 Phosphorylation HPRD   PhosphoSitePlus 19691289
K604 Ubiquitination PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
S646 Phosphorylation O14757 (CHEK1) , PR:O14757 (hCHEK1) PRO   PhosphoSitePlus   Signor 20719863
K653 Ubiquitination PhosphoSitePlus
K657 Acetylation PhosphoSitePlus
K661 Acetylation PhosphoSitePlus
K662 Acetylation PhosphoSitePlus
K662 Sumoylation PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
Y699 Phosphorylation PhosphoSitePlus
S714 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus 16880735
Y736 Phosphorylation PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
K755 Ubiquitination PhosphoSitePlus
T766 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus 16880735
K769 Ubiquitination PhosphoSitePlus
S773 Phosphorylation PhosphoSitePlus
K820 Sumoylation PhosphoSitePlus
K820 Ubiquitination PhosphoSitePlus
T830 Phosphorylation PhosphoSitePlus
T832 Phosphorylation PhosphoSitePlus
K839 Sumoylation PhosphoSitePlus
K839 Ubiquitination PhosphoSitePlus
K863 Acetylation PhosphoSitePlus   UniProt 19608861
K863 Ubiquitination PhosphoSitePlus
K873 Sumoylation PhosphoSitePlus
K873 Ubiquitination PhosphoSitePlus
T903 Phosphorylation PhosphoSitePlus
T907 Phosphorylation PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
K1082 Sumoylation PhosphoSitePlus
K1082 Ubiquitination PhosphoSitePlus
S1083 Phosphorylation PhosphoSitePlus
K1125 Sumoylation PhosphoSitePlus
K1125 Ubiquitination PhosphoSitePlus
K1133 Ubiquitination PhosphoSitePlus
S1197 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1199 Sumoylation PhosphoSitePlus
K1199 Ubiquitination PhosphoSitePlus
K1207 Ubiquitination PhosphoSitePlus
K1217 Ubiquitination PhosphoSitePlus
K1273 Sumoylation PhosphoSitePlus
K1273 Ubiquitination PhosphoSitePlus
S1280 Phosphorylation PhosphoSitePlus
S1290 Phosphorylation P33981 (TTK) PhosphoSitePlus 16864798
S1295 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18452278
S1296 Phosphorylation P33981 (TTK) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16864798, 15302935, 18452278, ...18669648, 20068231
S1303 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1304 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1310 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18452278
K1329 Ubiquitination PhosphoSitePlus
K1372 Sumoylation PhosphoSitePlus
K1372 Ubiquitination PhosphoSitePlus
S1375 Phosphorylation PhosphoSitePlus
S1383 Phosphorylation PhosphoSitePlus
K1411 Acetylation PhosphoSitePlus
S1417 Phosphorylation PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045543 (hBLM/Phos:1) p PRO 20719863
PR:000045543 (hBLM/Phos:1) pS646 PR:O14757 (hCHEK1) PRO 20719863
PR:000046485 (hBLM/Sumo:1) suK317,suK331,suK344,suK347 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K24 T24 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S33 L33 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S48 F48 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K105 N105 Biomuta DOID:1612 / breast cancer [ tcga ]
T125 P125 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S175 I175 Biomuta DOID:1324 / lung cancer [ tcga ]
S269 T269 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S304 Y304 Biomuta DOID:363 / uterine cancer [ tcga ]
S328 C328 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S336 I336 Biomuta DOID:3571 / liver cancer [ icgc ]
K344 N344 Biomuta DOID:1115 / sarcoma [ tcga ]
S449 C449 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S449 Y449 Biomuta DOID:363 / uterine cancer [ tcga ]
S462 Y462 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ]
K484 N484 Biomuta DOID:363 / uterine cancer [ tcga ]
K535 Q535 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S601 Y601 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K653 N653 Biomuta DOID:363 / uterine cancer [ tcga ]
K653 M653 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K741 N741 Biomuta DOID:363 / uterine cancer [ tcga ]
T830 M830 Biomuta DOID:2394 / ovarian cancer [ tcga ]
T907 R907 Biomuta DOID:1612 / breast cancer [ tcga ]
T907 M907 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S1280 L1280 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K1372 N1372 Biomuta DOID:10534 / stomach cancer [ tcga ]